Diphenyl sulfone

Diphenyl sulfone
  • CAS No.:127-63-9

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  1. This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
  2. This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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Diphenyl sulfone Basic information
Product Name:Diphenyl sulfone
Synonyms:Benzene, 1,1'-sulfonylbis-;Difenylsulfon;dlphenylsulfone;Phenyl sulphone;phenylsulphone;s-127;s-97;Sulfone, diphenyl
CAS:127-63-9
MF:C12H10O2S
MW:218.27
EINECS:204-853-1
Product Categories:Flexibilizer,acaricide and organic synthesis;Biochemistry;Color Former & Related Compounds;Diphenyl Sulfones (for High-Performance Polymer Research);Functional Materials;Reagent for High-Performance Polymer Research;Reagents for Oligosaccharide Synthesis;Sensitizer;127-63-9
Mol File:127-63-9.mol
Diphenyl sulfone Chemical Properties
Melting point 123-129 °C (lit.)
Boiling point 379 °C (lit.)
density 1.36
vapor pressure 0.001Pa at 50℃
refractive index 1.5200 (estimate)
Fp 184°C
storage temp. Sealed in dry,Room Temperature
solubility >14mg/l
form Crystalline Powder
color White
Water Solubility insoluble
Merck 14,3332
BRN 1910573
InChIKeyKZTYYGOKRVBIMI-UHFFFAOYSA-N
LogP2.61
CAS DataBase Reference127-63-9(CAS DataBase Reference)
NIST Chemistry ReferenceDiphenyl sulfone(127-63-9)
EPA Substance Registry SystemDiphenylsulfone (127-63-9)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-37/39
WGK Germany 3
RTECS SX2400000
TSCA Yes
HS Code 29309070
ToxicityLD50 orally in rats: >2 g/kg, Residue Rev. 36, 240 (1971)
MSDS Information
ProviderLanguage
Diphenyl sulfone English
SigmaAldrich English
ACROS English
ALFA English
Diphenyl sulfone Usage And Synthesis
Chemical PropertiesDiphenyl sulfone is a sulfone compound having two S-phenyl substituents. It is a crystalline powder that is soluble in organic solvents. It has been found in plants like Gnidia glauca and Dioscorea bulbifera. It has a role as a plant metabolite. Diphenyl sulfone is formed under certain conditions by the action of aqueous sulfuric acid on benzene. It is used as a high temperature solvent. Such high temperature solvents are useful for processing highly rigid polymers, e.g., PEEK, which only dissolve in very hot solvents.
UsesOvicide; acaricide.
UsesDiphenyl sulfone was identified as the preferred solvent. Diphenyl sulfone is chemically and thermally stable as compared to dimethyl sulfoxide.
UsesPhenyl Sulphone undergoes deoxygenation with Mg-MeOH at room temperature.
DefinitionChEBI: A sulfone compound having two S-phenyl substituents. It has been found in plants like Gnidia glauca and Dioscorea bulbifera.
Synthesis Reference(s)The Journal of Organic Chemistry, 50, p. 1784, 1985 DOI: 10.1021/jo00210a053Synthesis, p. 342, 1974Tetrahedron Letters, 21, p. 689, 1980 DOI: 10.1016/S0040-4039(00)71446-8
Flammability and ExplosibilityNotclassified
Purification MethodsCrystallise the sulfone from diethyl ether. It has been purified by zone melting. [Beilstein 6 H 300, 6 IV 1490.]

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