Other grades of this product :
| CYCLO(-LEU-PRO) Basic information |
| Product Name: | CYCLO(-LEU-PRO) | | Synonyms: | 2-a)pyrazine-1,4-dione,hexahydro-3-isobutyl-pyrrolo(stereoisomer;4-dione,hexahydro-3-(2-methylpropyl)-2-a)pyrazine-(3s-trans)-pyrrolo(;cyclo-l-leu-l-pro;gancidinw;(3S-trans)-hexahydro-3-isobutylpyrrolo[1,2-a]pyrazine-1,4-dione;(3S,8aS)-2,3,6,7,8,8a-Hexahydro-3-(2-methylpropyl)pyrrolo[1,2-a]pyrazine-1,4-dione;(3S,8aS)-Octahydro-3-(2-methylpropyl)pyrrolo[1,2-a]pyrazine-1,4-dione;Cyclo(L-leucyl-L-prolyl-) | | CAS: | 2873-36-1 | | MF: | C11H18N2O2 | | MW: | 210.27 | | EINECS: | 220-710-6 | | Product Categories: | | Mol File: | 2873-36-1.mol |
| CYCLO(-LEU-PRO) Chemical Properties |
| Melting point | 163-165℃ | | Boiling point | 427.6±34.0 °C(Predicted) | | density | 1.14 | | storage temp. | Inert atmosphere,2-8°C | | solubility | Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly) | | form | Solid | | pka | 13.27±0.40(Predicted) | | color | White to Off-White |
| CYCLO(-LEU-PRO) Usage And Synthesis |
| Description | Cyclo(L-Leu-L-Pro) is a diketopiperazine metabolite that has been isolated from various bacterial and fungal species including Streptomyces. It is active against twelve strains of vancomycin-resistant enterococci (VRE) with MIC values of 12.5 μg/ml for E. faecalis strains K-99-34, K-00-184, and K-00-221. It also inhibits growth of K562, HL-60, and U937 leukemia cells in a concentration-dependent manner when used at concentrations of 1-500 μg/ml. Cyclo(L-Leu-L-Pro) also has antifouling activity, inhibiting attachment of B. amphitrite larva with an EC50 value of 0.15 mM. | | Chemical Properties | White Solid | | Uses | Sorbicillin analog. A bioactive secondary metabolites from terrestrial Streptomyces species TN262. | | Definition | ChEBI: A homodetic cyclic peptide composed from leucyl and prolyl residues. |
| CYCLO(-LEU-PRO) Preparation Products And Raw materials |
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