2-Butyl-4-chloro-5-formylimidazole Five Chongqing Chemdad Co. ，Ltd

Product

2-Butyl-4-chloro-5-formylimidazole

CAS No.：83857-96-9

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2-Butyl-4-chloro-5-formylimidazole Basic information

Product Name:	2-Butyl-4-chloro-5-formylimidazole
Synonyms:	2-BUTYL-4-CHLORO-5-IMIDAZOLECARBOXALDEHYDE (BCFI);2-Butyl-4-chloroimidazole-5-carboxaldehyde;2-Butyl-5-formyl-4-chloroimidazole;2-butyl-5-chloro-3H-imidazole-4-carbaldehyde;2-Butyl-5-chloro-4-formylimidazole 97%;2-BUTYL-5-CHLORO-1H-IMIDAGOLE-;2-N-BUTYL-4(5)-CHLORO-1H-IMIDAZOLE-5(4)-CARBOXALDEHYDE (INTERMEDIATE OF LOSARTAN);2-n-Butyl-4-chloro-5-formylimidazloe
CAS:	83857-96-9
MF:	C8H11ClN2O
MW:	186.64
EINECS:	410-260-0
Product Categories:	Building Blocks;C8;(intermediate of losartan);Heterocyclic Compounds;Hypertension;Carbonyl Compounds;INTERMEDIATESOF;Aldehydes;Imidazoles & Benzimidazoles;Heterocycles;Imidazoles & Benzimidazoles;Chemical Synthesis;api;Intermediates;Halogenated Heterocycles;Heterocyclic Building Blocks;Imidazoles;Organic Building Blocks
Mol File:	83857-96-9.mol

2-Butyl-4-chloro-5-formylimidazole Chemical Properties

Melting point	97-100 °C(lit.)
Boiling point	384.1±22.0 °C(Predicted)
density	1.240
vapor pressure	0.001Pa at 25℃
storage temp.	Inert atmosphere,2-8°C
solubility	slightly soluble
form	neat
pka	8.87±0.10(Predicted)
color	Pale Yellow to Brown
Water Solubility	slightly soluble
InChIKey	JLVIHQCWASNXCK-UHFFFAOYSA-N
LogP	2.5 at 25℃ and pH7.1
Surface tension	58.3mN/m at 1.2g/L and 20℃
CAS DataBase Reference	83857-96-9(CAS DataBase Reference)
EPA Substance Registry System	2-Butyl-5-chloroimidazole-4-carbaldehyde (83857-96-9)

Safety Information

Hazard Codes	Xi,N
Risk Statements	43-51/53
Safety Statements	24-37-61
RIDADR	UN 3077 9/PG 3
WGK Germany	2
HazardClass	IRRITANT
PackingGroup	III
HS Code	29339900

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English

2-Butyl-4-chloro-5-formylimidazole Usage And Synthesis

Chemical Properties	2-Butyl-4-chloro-5-formylimidazole is Yellow Solid
Uses	2-Butyl-4-chloro-5-formylimidazole is used for preparation of N-(biphenylylmethyl)imidazoles as angiotensin II antagonists
Uses	2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde may be used in the preparation of the following symmetrical esters of dialkyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate: dimethyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate diethyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate diisopropyl 4-(2-butyl-5-chloro-1Himidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate diisobutyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate di-tert-butyl 4-(2-butyl-5-chloro-1Himidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate bis(2-methoxyethyl) 4-(2-butyl-5-chloro-1Himidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Application	2-Butyl-4-chloro-1H-imidazole-5-carboxaldehyde (Losartan EP Impurity D) is used for preparation of N-(biphenylylmethyl)imidazoles as angiotensin II antagonists. Losartan USP Related Compound A.
Synthesis Reference(s)	The Journal of Organic Chemistry, 64, p. 8084, 1999 DOI: 10.1021/jo9824910

2-Butyl-4-chloro-5-formylimidazole Preparation Products And Raw materials

Preparation Products

4’-[(2-butyl-4-chloro-5-hydroxymethyl)-1H-imidazol-1-yl)methyl]-[1,1’-Biphenyl]-2-carbonitrile-->(2-BUTYL-5-CHLORO-1H-IMIDAZOL-4-YL)METHANOL-->EPROSARTAN

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