TRI(ETHYLENE GLYCOL) DI-P-TOLUENESULFONATE

CAS No.：19249-03-7

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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TRI(ETHYLENE GLYCOL) DI-P-TOLUENESULFONATE Basic information

Product Name:	TRI(ETHYLENE GLYCOL) DI-P-TOLUENESULFONATE
Synonyms:	1,10-Ditosyl-1,4,7,10-tetraoxadecane;1,8-Bis(tosyloxy)-3,6-dioxaoctane;Bis(4-methylbenzenesulfonic acid)3,6-dioxa-1,8-octanediyl ester;Bis(4-methylbenzenesulfonic acid)ethylenebis(oxyethylene) ester;Bis(p-toluenesulfonic acid)ethylenebisoxybisethylene ester;Triethylene glycol di-p-tosylate,98%;Triethleneglycol ditosylate;Triethylene glycol ditoluenesulfonate.
CAS:	19249-03-7
MF:	C20H26O8S2
MW:	458.55
EINECS:	628-844-0
Product Categories:
Mol File:	19249-03-7.mol

TRI(ETHYLENE GLYCOL) DI-P-TOLUENESULFONATE Chemical Properties

Melting point	78-82 °C(lit.)
Boiling point	534.03°C (rough estimate)
density	1.3164 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Soluble in ethanol.
form	powder to crystal
color	White to Almost white
BRN	632509
InChIKey	KCONMNWPRXAWKK-UHFFFAOYSA-N
CAS DataBase Reference	19249-03-7(CAS DataBase Reference)
EPA Substance Registry System	Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-, bis(4-methylbenzenesulfonate) (19249-03-7)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
HS Code	29093090

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English
ALFA	English

TRI(ETHYLENE GLYCOL) DI-P-TOLUENESULFONATE Usage And Synthesis

Description	Tos-PEG4-Tos is a PEG linker containing two tosyl groups. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions.
Chemical Properties	WHITE POWDER
Uses	Tri(ethylene glycol) di-p-toluenesulfonate is used in the synthesis of 1-[4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-phenyl] ethanone.

TRI(ETHYLENE GLYCOL) DI-P-TOLUENESULFONATE Preparation Products And Raw materials

Preparation Products

Ethane, 1,2-bis(2-bromoethoxy)--->2-[2-(2-Fluoroethoxy)ethoxy]ethanol-->2-[2-(2-Azidoethoxy)ethoxy]ethanamine-->1,2-Bis(2-chloroethoxy)ethane

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