| N-Hydroxyethylphthalimide Basic information |
| Product Name: | N-Hydroxyethylphthalimide |
| Synonyms: | AKOS BBS-00004429;2-PHTHALIMIDOETHANOL;2-(2-hydroxyethyl)-1h-isoindole-1,3(2h)-dione;N-HYDROXYETHYLPHTHALIMIDE;N-(2-HYDROXYETHYL)PHTHALIMIDE;N-(BETA-HYDROXYETHYL)PHTHALIMIDE;TIMTEC-BB SBB003638;1H-Isoindole-1,3(2H)-dione, 2-(2-hydroxyethyl)- |
| CAS: | 3891-07-4 |
| MF: | C10H9NO3 |
| MW: | 191.18 |
| EINECS: | 223-434-4 |
| Product Categories: | Building Blocks;Carbonyl Compounds;N-Substituted Maleimides, Succinimides & Phthalimides;Chemical Synthesis;Cyclic Imides;Organic Building Blocks;N-Substituted Phthalimides;bc0001 |
| Mol File: | 3891-07-4.mol |
| N-Hydroxyethylphthalimide Chemical Properties |
| Melting point | 126-128 °C(lit.) |
| Boiling point | 326.92°C (rough estimate) |
| density | 1.2722 (rough estimate) |
| refractive index | 1.5310 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Crystalline Powder |
| pka | 14.40±0.10(Predicted) |
| color | White |
| BRN | 147214 |
| InChIKey | MWFLUYFYHANMCM-UHFFFAOYSA-N |
| CAS DataBase Reference | 3891-07-4(CAS DataBase Reference) |
| NIST Chemistry Reference | N-2-hydroxyethyl phthalimide(3891-07-4) |
| EPA Substance Registry System | 1H-Isoindole-1,3(2H)-dione, 2-(2-hydroxyethyl)- (3891-07-4) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 22-26-36/37/39-24/25 |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29251900 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| ACROS | English |
| ALFA | English |
| N-Hydroxyethylphthalimide Usage And Synthesis |
| Chemical Properties | white crystalline powder |
| Uses | N-(2-Hydroxyethyl)phthalimide is used as a reagent to synthesize (-)-R-rolipram is a phosphodiesterase 4 inhibitor that is used to treat depression. N-(2-Hydroxyethyl)phthalimide is also used as a reagent to synthesize FR252921, a compound that acts as an immunosuppressant. Amlodipine Impurity 6 |
| Synthesis Reference(s) | Organic Syntheses, Coll. Vol. 4, p. 106, 1963The Journal of Organic Chemistry, 24, p. 1122, 1959 DOI: 10.1021/jo01090a601 |
| General Description | N-(2-Hydroxyethyl)phthalimide is the precursor for chloromethyl ethers used in the synthesis of purine acyclic nucleosides. |
| N-Hydroxyethylphthalimide Preparation Products And Raw materials |
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