4-Hydroxy-3-nitropyridine

CAS No.：5435-54-1

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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4-Hydroxy-3-nitropyridine Basic information

Product Name:	4-Hydroxy-3-nitropyridine
Synonyms:	3-NITROPYRIDIN-4-OL;3-NITRO-4-PYRIDINOL;4-Hydroxy-3-Nitropyridine 3-Nitro-4-pyridinol;3-nitro-4-hydroxypyridine;4-HYDROXY-3-NITROPRIDINE;4-Pyridinol,3-nitro-(6CI,7CI,9CI);4-hydroxy-3-nitropytidine;4-Hydroxy-3-nitropyridine
CAS:	5435-54-1
MF:	C5H4N2O3
MW:	140.1
EINECS:	611-127-1
Product Categories:	pharmacetical;Pyridines derivates;NITRO;Pyridine;bc0001
Mol File:	5435-54-1.mol

4-Hydroxy-3-nitropyridine Chemical Properties

Melting point	285 °C (dec.) (lit.)
Boiling point	382.1±22.0 °C(Predicted)
density	1.507±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
pka	0.13±0.14(Predicted)
BRN	1072928
InChIKey	YUWOLBZMQDGRFV-UHFFFAOYSA-N
CAS DataBase Reference	5435-54-1(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-36/37/39-22
WGK Germany	3
Hazard Note	Toxic
HazardClass	IRRITANT, IRRITANT-HARMFUL
HS Code	29333990

MSDS Information

Provider	Language
ACROS	English
ALFA	English

4-Hydroxy-3-nitropyridine Usage And Synthesis

Chemical Properties	Light yellow crystalline powder
Uses	4-Hydroxy-3-nitropyridine may be used in the synthesis of 4-ethoxy-3-nitropyridine by treating with phosphorus pentachloride (PCl₅) followed by ethanol. It may also be used to prepare 4-chloro-3-nitropyridine by treating with PCl₅-POCl₃ (phosphorus oxychloride).
General Description	4-Hydroxy-3-nitropyridine can be synthesized by the nitration of 4-hydroxypyridine.

4-Hydroxy-3-nitropyridine Preparation Products And Raw materials

Preparation Products

3-Amino-4-chloropyridine-->3-Amino-4-ethoxypyridine-->4-Chloro-3-nitropyridine-->4-Ethoxy-3-nitropyridine-->4-bromo-1H-pyrrolo[2,3-c]pyridine-->4-Amino-3-nitropyridine-->3-Bromo-4-methyl-5-nitropyridine-->2,4-DICHLORO-5-NITROPYRIDINE

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