2-Amino-3-picoline

CAS No.：1603-40-3

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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2-Amino-3-picoline Basic information

Product Name:	2-Amino-3-picoline
Synonyms:	AURORA KA-876;2-AMINO-3-PICOLINE 96%;2-amino-3-methyl-pyridin;2-Amino-beta-picoline;2-Pyridinamine,3-methyl-;3-Methyl-2-aminopyridine;3-methyl-2-pyridinamin;3-Methyl-2-pyridinamine
CAS:	1603-40-3
MF:	C6H8N2
MW:	108.14
EINECS:	216-501-4
Product Categories:	amine;Pyridine;VARIOUSAMINE;Pyridines, Pyrimidines, Purines and Pteredines;Pyridine series;Pyridines derivates;bc0001
Mol File:	1603-40-3.mol

2-Amino-3-picoline Chemical Properties

Melting point	29-31 °C (lit.)
Boiling point	221-222 °C (lit.)
density	1.073 g/mL at 25 °C (lit.)
refractive index	n20/D 1.5823(lit.)
Fp	233 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	1000g/l
form	Liquid After Melting
pka	pK1: 7.24(+1) (25°C)
color	Clear yellow
Water Solubility	SOLUBLE
Sensitive	Hygroscopic
BRN	107892
InChIKey	RGDQRXPEZUNWHX-UHFFFAOYSA-N
CAS DataBase Reference	1603-40-3(CAS DataBase Reference)
NIST Chemistry Reference	2-Pyridinamine, 3-methyl-(1603-40-3)
EPA Substance Registry System	2-Pyridinamine, 3-methyl- (1603-40-3)

Safety Information

Hazard Codes	T
Risk Statements	23/24/25-33-36/37/38-25
Safety Statements	36/37/39-45-37/39-28A-26
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	US1850000
TSCA	Yes
HazardClass	6.1
PackingGroup	II
HS Code	29333999

MSDS Information

Provider	Language
2-Amino-3-picoline	English
SigmaAldrich	English
ACROS	English
ALFA	English

2-Amino-3-picoline Usage And Synthesis

Chemical Properties	2-Amino-3-picoline is CLEAR YELLOW LIQUID AFTER MELTING
Uses	2-Amino-3-picoline is used in the synthesis of ketones from aldehydes.
Synthesis Reference(s)	Journal of the American Chemical Society, 95, p. 4453, 1973 DOI: 10.1021/ja00794a070
Hazard	Toxic by ingestion.
Purification Methods	Recrystallise the picoline three times from benzene, most of the residual benzene being removed from the crystals by standing over paraffin wax chips in an evacuated desiccator. The amine is also transferred to a separating funnel under N2, and left in contact with NaOH pellets for 3hours with occasional shaking. It is then placed in a vacuum distilling flask where it is refluxed gently in a stream of dry N2 before fractionally distilling it. [Mod et al. J Phys Chem 60 1651 1956, Beilstein 22/9 V 212].

2-Amino-3-picoline Preparation Products And Raw materials

Preparation Products

2-AMINO-4-METHOXYPYRIDINE-3-CARBOXYLIC ACID-->5-Amino-2-chloro-3-picoline-->4-METHOXY-3-METHYLPYRIDIN-2-AMINE-->2-Chloro-5-cyano-3-methylpyridine-->2-(2,2,2-TRIFLUOROETHOXY)PYRIDINE-3-CARBOXYLIC ACID-->2-CHLORO-4-METHOXY-3-METHYLPYRIDINE-->1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL--->2-CHLORO-3-METHYL-4-METHOXYPYRIDINE N-OXIDE-->2-Amino-5-hydroxypyridine-->2-CHLORO-5-IODO-3-METHYLPYRIDINE-->2-CHLORO-3-METHYL-4-NITROPYRIDINE N-OXIDE-->2-ACETAMIDOPYRIDINE-3-CARBOXYLIC ACID-->2-BROMO-3-METHYLPYRIDINE-5-BORONIC ACID-->2-(Trifluoromethyl)nicotinic acid-->2-Bromo-3-methylpyridine-->2-NITRONICOTINIC ACID-->2-CHLORO-3-METHYLPYRIDINE-5-BORONIC ACID-->2-Amino-5-bromo-3-methylpyridine-->3-Methyl-2-nitropyridine-->6-AMINO-5-METHYLNICOTINONITRILE-->2,5-DIBROMONICOTINALDEHYDE-->2-Amino-3-methyl-5-nitropyridine-->FMOC-2-AMINONICOTINIC ACID-->2-AMINO-5-NITROPYRIDINE-3-CARBOXYLIC ACID-->(2-Aminopyridin-3-yl)methanol-->2-AMINO-5-CHLORO-3-PICOLINE-->2-HYDROXY-3-METHYL-5-NITROPYRIDINE-->Ethyl 2-aminopyridine-3-carboxylate-->2-Chloro-3-methyl-5-bromopyridine-->PEMIROLAST-->2-ACETAMIDO-3-PICOLINE-->6-AMINO-5-METHYLPYRIDINE-3-SULFONIC ACID

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