2-Chloro-5-trifluoromethylpyridine

CAS No.：52334-81-3

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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2-Chloro-5-trifluoromethylpyridine Basic information

Synthesis

Product Name:	2-Chloro-5-trifluoromethylpyridine
Synonyms:	2-choro-5-(trifluoromethyl) pyridine;2-chloro-5-(trifluoromethyl)-pyridin;2-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE;2,5-CTF;2 - chloro - 5-3 Methyl pyridine;5-CTF;2-chlorine-5-trifluoromethyl pyridine;oro-5-(trifL
CAS:	52334-81-3
MF:	C6H3ClF3N
MW:	181.54
EINECS:	257-856-5
Product Categories:	Fluorine series;API Intermediate;Chloropyridines;Halopyridines;C6Heterocyclic Building Blocks;Halogenated Heterocycles;blocks;FluoroCompounds;Pyridines;Pyridines, Pyrimidines, Purines and Pteredines;Pyridine series;Halides;Pyridines derivates;Heterocyclic Building Blocks;Pyridine;bc0001
Mol File:	52334-81-3.mol

2-Chloro-5-trifluoromethylpyridine Chemical Properties

Melting point	32-34 °C(lit.)
Boiling point	152 °C
density	1.417 g/mL at 25 °C(lit.)
Fp	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	Crystalline Low Melting Solid
pka	-2.57±0.10(Predicted)
Specific Gravity	1.417
color	White to yellow
BRN	3649688
InChIKey	JFZJMSDDOOAOIV-UHFFFAOYSA-N
CAS DataBase Reference	52334-81-3(CAS DataBase Reference)
EPA Substance Registry System	Pyridine, 2-chloro-5-(trifluoromethyl)- (52334-81-3)

Safety Information

Hazard Codes	Xi,Xn,T,F
Risk Statements	36/37/38-20/21/22-25-11
Safety Statements	26-37/39-36/37/39-45-22-16
RIDADR	2811
WGK Germany	3
RTECS	US7530000
Hazard Note	Irritant
TSCA	T
HazardClass	6.1
PackingGroup	III
HS Code	29339900

MSDS Information

Provider	Language
2,5-CTF	English
ACROS	English
SigmaAldrich	English
ALFA	English

2-Chloro-5-trifluoromethylpyridine Usage And Synthesis

Synthesis	2-Chloro-5-trifluoromethylpyridine can be synthesized by fluorination of 2-chloro-5-trichloromethylpyridine.
Chemical Properties	white to yellowish crystalline low melting solid
Uses	2-Chloro-5-(trifluoromethyl)pyridine may be employed as model substrate to investigate the regioexhaustive functionalization.
General Description	2-Chloro-5-(trifluoromethyl)pyridine is a chloro(trifluoromethyl) pyridine.

2-Chloro-5-trifluoromethylpyridine Preparation Products And Raw materials

Raw materials	Hydrogen fluoride-->3-Picoline-->2-Chloro-5-methylpyridine-->2-Chloro-5-trichloromethylpyridine-->2-Chloro-3-(trifluoromethyl)pyridine-->3-(trifluoromethyl)pyridine 1-oxide
Preparation Products	Fluazifop-P-butyl-->1-[5-(Trifluoromethyl)pyridin-2-yl]piperazine-->Fluazifop-butyl-->PF-04457845-->5-TRIFLUOROMETHYL-PYRIDINE-2-CARBOXYLICACIDMETHYLESTER-->2,6-Dichloro-3-(trifluoromethyl)pyridine-->5-(Trifluoromethyl)pyridine-2-carboxylic acid

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