2'-Deoxy-L-thymidine

CAS No.：3424-98-4

Other grades of this product :

2'-Deoxy-L-thymidine Basic information

Product Name:	2'-Deoxy-L-thymidine
Synonyms:	BETA-L-THYMIDINE;2'-DEOXY-L-THYMIDINE;L-Thymidine(Telbivudine);1-[(2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione;Β-L-2'-DEOXY-THYMIDINE;2'-Deoxy-L-thyMidine(Telbivudine);Telbivudine(Tyzeka, Sebivo);1-(2-Deoxy-β-L-erythro-pentofuranosyl)-5-Methyl-
CAS:	3424-98-4
MF:	C10H14N2O5
MW:	242.23
EINECS:	608-961-3
Product Categories:	Anti-virals;Bases & Related Reagents;Carbohydrates & Derivatives;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;API intermediates;Amines;API;Chiral Reagents;Heterocycles
Mol File:	3424-98-4.mol

2'-Deoxy-L-thymidine Chemical Properties

Melting point	188-190°C
alpha	D20 -20.3° (c = 0.192 in water)
density	1.452±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	H2O: soluble10mg/mL (clear solution)
form	powder
pka	9.55±0.10(Predicted)
color	white to beige
optical activity	[α]/D -15 to -22°, c = 1 in H2O
InChIKey	IQFYYKKMVGJFEH-CSMHCCOUSA-N

Safety Information

Hazard Codes	Xn
Risk Statements	22
Safety Statements	24/25
WGK Germany	3
RTECS	UV9048500
HS Code	29349990

MSDS Information

2'-Deoxy-L-thymidine Usage And Synthesis

Description	Telbivudine is a b-L-thymidine nucleoside analog launched for the once-daily oral treatment of chronic hepatitis B virus (HBV) infection. It is the fourth nucleoside or nucleotide analog to be marketed for this indication. The previous drugs from this class include lamivudine, a deoxythiacytosine analog, adefovir, a nucleotide analog, and entecavir, a guanosine analog. Adefovir, entecavir, and telbivudine are specifically indicated for HBV, whereas lamivudine is indicated for both HBV and HIV infections. Telbivudine is efficiently phosphorylated by cellular kinases to the active triphosphate derivative, which inhibits HBV DNA polymerase by competing with the natural substrate, thymidine- 5’-triphosphate.
Chemical Properties	2'-Deoxy-L-thymidine is White Solid
Originator	Idenix (US)
Uses	Nucleoside analog; specific inhibitor of hepatitis B virus (HBV) replication. Antiviral.
Uses	Nucleoside analog; specific inhibitor of hepatitis B virus (HBV) replication. Antiviral
Uses	Telbivudine(Tyzeka, Sebivo) is an antiviral drug used in the treatment of hepatitis B infection. Clinical trials have shown it to be significantly more effective than lamivudine or adefovir, and less likely to cause resistance. Telbivudine is a synthetic
Definition	ChEBI: A pyrimidine 2'-deoxyribonucleoside that is the L-enantiomer of thymine. A synthetic thymidine nucleoside analogue with activity against HBV DNA polymerase.
Brand name	(Novirio).

2'-Deoxy-L-thymidine Preparation Products And Raw materials

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