| 4-(1-Acetylpiperazin-4-yl)phenol Basic information |
| Product Name: | 4-(1-Acetylpiperazin-4-yl)phenol |
| Synonyms: | TIMTEC-BB SBB003353;N-ACETYL-4-HYDROXYPHENYL PIPERAZINE;N-ACETYL-4-(4-HYDROXYPHENYL)PIPERAZINE;1-Acetyl-4-(4-hydroxyphenyl)piperazine, 98+%;1-[4-(4-Hydroxyphenyl)piperazin-1-yl]ethanon;Piperazine, 1-acetyl-4-(4-hydroxyphenyl)-;1-Acetyl-4-(4-Hydroxy-Phenyl)PiperazineKetoconazole;4-(4-Acetylpiperazino)phenol |
| CAS: | 67914-60-7 |
| MF: | C12H16N2O2 |
| MW: | 220.27 |
| EINECS: | 267-744-8 |
| Product Categories: | Piperaizine;Miscellaneous;Chemical Amines;Amines;Aromatics;Intermediates & Fine Chemicals;Chemical intermediate for Ketoconazole;Piperidines, Piperidones, Piperazines;Pharmaceuticals;Building Blocks;Heterocyclic Building Blocks;Piperazines |
| Mol File: | 67914-60-7.mol |
| 4-(1-Acetylpiperazin-4-yl)phenol Chemical Properties |
| Melting point | 180-185 °C (lit.) |
| Boiling point | 361.21°C (rough estimate) |
| density | 1.1115 (rough estimate) |
| vapor pressure | 0Pa at 20℃ |
| refractive index | 1.6000 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Powder |
| pka | 12.18±0.30(Predicted) |
| color | White to slightly pink or beige |
| Water Solubility | 4.3 g/L (20 ºC) |
| BRN | 795777 |
| InChIKey | AGVNLFCRZULMKK-UHFFFAOYSA-N |
| LogP | 0.3 |
| CAS DataBase Reference | 67914-60-7(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-22 |
| Safety Statements | 26-36-36/37/39-22 |
| WGK Germany | 3 |
| HS Code | 29214910 |
| MSDS Information |
| Provider | Language |
|---|---|
| 1-[4-(4-Hydroxyphenyl)piperazino]ethan-1-one | English |
| ACROS | English |
| SigmaAldrich | English |
| ALFA | English |
| 4-(1-Acetylpiperazin-4-yl)phenol Usage And Synthesis |
| Chemical Properties | Off-White Solid |
| Uses | 1-Acetyl-4-(4-hydroxyphenyl)piperazine may be used in the preparation of 1-acetyl-4-(4-octadecyloxyphenyl)piperazine. It may also be used in the multi-step synthesis of ketoconazole, its 1,2,4-triazole and thiazole analogs. |
| General Description | 1-Acetyl-4-(4-hydroxyphenyl)piperazine (AHPP), a piperazine derivative, is a structural analog of acetaminophen. Its multi-step preparation using bis-(2-chloroethyl)amine hydrochloride and p-aminophenol as starting materials has been reported.2 |
| Flammability and Explosibility | Notclassified |
| 4-(1-Acetylpiperazin-4-yl)phenol Preparation Products And Raw materials |
| Raw materials | 4-Chloronitrobenzene-->PIPERAZINE HEXAHYDRATE-->1-(4-Nitrophenyl)piperazine-->1-Acetyl-4-(4-nitrophenyl)piperazine |
| Preparation Products | Itraconazole |
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