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| 4'-AMINOPROPIOPHENONE Basic information |
| 4'-AMINOPROPIOPHENONE Chemical Properties |
| Melting point | 135-140 °C | | Boiling point | 270.27°C (rough estimate) | | density | 1.067±0.06 g/cm3 (20 ºC 760 Torr) | | refractive index | 1.5279 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | pka | 2.86±0.10(Predicted) | | color | Needles from water | | Water Solubility | 352.1mg/L(37.5 ºC) | | CAS DataBase Reference | 70-69-9(CAS DataBase Reference) | | EPA Substance Registry System | p-Aminopropiophenone (70-69-9) |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45-28A | | RIDADR | 2811 | | HazardClass | 6.1(b) | | PackingGroup | III | | HS Code | 29223990 | | Hazardous Substances Data | 70-69-9(Hazardous Substances Data) | | Toxicity | LD50 in male, female mice (mg/kg): 145, 200 i.v.; in female mice, guinea pigs, rats, male rats (mg/kg): >5000, 1020, 223.7, 475 orally (Scawin) |
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ACROS
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| 4'-AMINOPROPIOPHENONE Usage And Synthesis |
| Chemical Properties | yellow-brown crystalline powder, scales | | Uses | 4''-Aminopropiophenone is used in method for preparing high-strength carbon nanotube film by thiol-ene click reaction. | | Preparation | The preparation of 4'-aminopropiophenone is as follows:A reaction tube was charged with the 2-aryloxypropanamide (1.0 mmol), potassium hydroxide (56 mg, 1.0 mmol) and DMSO (4 mL). The mixture was heated at 140 C for 3-8 h. The reaction was monitored by TLC. After the reaction period, the reaction mixture was cooled, diluted with saturated brine and extracted with dichloromethane three times. The combined organic layers were washed with three portions of saturated brine and then dried over MgSO4 and filtered. Solvent was removed under reduced pressure. The product was purified through flash column chromatography on 300-400 mesh silica gel with petroleum ether/ethyl acetate as eluent. | | General Description | Yellow needles. | | Reactivity Profile | 4'-AMINOPROPIOPHENONE is simultaneously a ketone and an amine. Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides. | | Safety Profile | Poison by ingestion and intraperitoneal routes. Ingestion of large doses can cause cyanosis. A flammable liquid. When heated to decomposition it emits toxic fumes of NOx,. | | Purification Methods | Crystallise it from water or aqueous EtOH. The hydrochloride has m 188-189o (aqueous EtOH/HCl drops), and the semicarbazone has m 139-140o (from EtOH/H2O). [Derrick & Bornemann J Am chem. Soc 35 1283 1913, Beilstein 14 H 59, 14 I 375, 14 III 146, 14 IV 139.] |
| 4'-AMINOPROPIOPHENONE Preparation Products And Raw materials |
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