POLY-L-ARGININE HYDROCHLORIDE

CAS No.：26982-20-7

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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POLY-L-ARGININE HYDROCHLORIDE Basic information

Product Name:	POLY-L-ARGININE HYDROCHLORIDE
Synonyms:	POLY-L-ARGININE HCL;POLY-L-ARGININE HYDROCHLORIDE;poly-L-arginine hcl mol wt 70000-150000;poly-L-arginine hydrochloride mol. wt.*5000-15000;POLY-L-ARGININE HCL MOL WT 15000-70000;mw10000-20000;L-ARGININE, HOMOPOLYMER, HYDROCHLORIDE;POLY-L-ARGININE HCL MOL WT 15000-700
CAS:	26982-20-7
MF:	C6H14N4O2
MW:	174.2
EINECS:
Product Categories:	Amino Acids;Homopolymers;Polyamino Acids
Mol File:	26982-20-7.mol

POLY-L-ARGININE HYDROCHLORIDE Chemical Properties

storage temp.

-20°C

Safety Information

WGK Germany

MSDS Information

Provider	Language
SigmaAldrich	English

POLY-L-ARGININE HYDROCHLORIDE Usage And Synthesis

Uses	Poly-L-arginine hydrochloride has been used: as polyelectrolyte solution in the synthesis of biodegradable capsules as layer constituent, in the preparation of layer by layer (LbL) assembly of multilayer biodegradable shells in assay for the determination of binding activity of C-reactive protein for polycationic ligands
Uses	Poly-L-arginine hydrochloride has been used: to generate complex with stimulatory RNA isRNA9.2 as in neutrophils used in ribosomal RNA transfection into human monocytic THP-1 cells for coating alginate capsule beads
General Description	Poly-L-arginine hydrochloride (PLA) is a homopolyamino acid. PLA enhances membrane permeability compared to poly-L-lysine. It has applications as drug carrier, neuroprotective agent and in anticancer vaccines preparations. Peptide vaccines in conjugation with PLA promotes antigen-presenting cells (APCs) to generate T cell and elicit immunostimulant functionality.
Biochem/physiol Actions	Poly-L-arginine (PLA) possesses anti-bacterial activity. It has a greater capacity to enhance membrane permeability. PLA at lower concentration enhances cell proliferation and at higher concentration acts as antiproliferative agent.

POLY-L-ARGININE HYDROCHLORIDE Preparation Products And Raw materials

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