Product

Methyl 3-amino-2-thiophenecarboxylate

CAS No.：22288-78-4

Other grades of this product :

Methyl 3-amino-2-thiophenecarboxylate Basic information

Product Name:	Methyl 3-amino-2-thiophenecarboxylate
Synonyms:	AMino-2-thiophenecarboxylate;AMino thiophene - 2-3 - carboxylic acid Methyl ester;Methyl3-aMino-2-thiophenecarbo;RARECHEM AM UC 0123;3-amino-2-thiophenecarboxylicacimethylester;ina-5545-2;Methyl3-amino-2-thenoate;3-AMINO-2-METHOXYCARBONYLTHIOPHENE
CAS:	22288-78-4
MF:	C6H7NO2S
MW:	157.19
EINECS:	244-895-8
Product Categories:	API intermediates;Thiophenes & Benzothiophenes;Sulphur Derivatives;INTERMEDIATESOFTENOXICAM;Esters;Pharmaceutical intermediate;Amino Acids and Derivatives;Heterocycles;Thiophenes & Benzothiophenes;Thiophene&Benzothiophene;Building Blocks;Heterocyclic Building Blocks;Thiophenes;Pyridines;bc0001
Mol File:	22288-78-4.mol

Methyl 3-amino-2-thiophenecarboxylate Chemical Properties

Melting point	62-64 °C (lit.)
Boiling point	100-102 °C/0.1 mmHg (lit.)
density	1.274 (estimate)
refractive index	1.5500 (estimate)
Fp	100-102°C/0.1mm
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	1.86±0.10(Predicted)
form	Fine Crystalline Powder
color	Beige to beige-brown
Water Solubility	Slightly soluble in water.
BRN	1365614
InChIKey	TWEQNZZOOFKOER-UHFFFAOYSA-N
CAS DataBase Reference	22288-78-4(CAS DataBase Reference)
EPA Substance Registry System	2-Thiophenecarboxylic acid, 3-amino-, methyl ester (22288-78-4)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-37/39-36/37/39-22
WGK Germany	3
RTECS	XM8347500
TSCA	Yes
HazardClass	IRRITANT
HS Code	29349990

MSDS Information

Provider	Language
Methyl 3-aminothiophene-2-carboxylate	English
SigmaAldrich	English
ACROS	English
ALFA	English

Methyl 3-amino-2-thiophenecarboxylate Usage And Synthesis

Chemical Properties	white to light yellow crystal powder
Uses	Methyl 3-amino-2-thiophenecarboxylate was used in: the synthesis of 4-nitro and 4-aminothienyl ureas total synthesis of quinazolinocarboline alkaloids preparation of thienopyrimidinone analogs
General Description	Methyl 3-amino-2-thiophenecarboxylate reacts with hydrazonoyl chlorides in the presence of triethylamine to yield corresponding N-arylamidrazones.

Methyl 3-amino-2-thiophenecarboxylate Preparation Products And Raw materials

Raw materials

Acrylonitrile-->Methyl thioglycolate-->1.3-Dichloropropene-->3-Chloroacrylonitrile-->3-Aminothiophene-2-carboxylic acid-->METHYL 3-OXOTETRAHYDROTHIOPHENE-2-CARBOXYLATE-->3-Pyridinecarboxaldehyde-->2-Chloroacrylonitrile

Preparation Products

METHYL 3-CHLOROTHIOPHENE-2-CARBOXYLATE-->Methyl 3-aminosulfonylthiophene-2-carboxylate-->3-CHLOROTHIOPHENE-2-CARBOXAMIDE-->3-(1H-PYRROL-1-YL)THIOPHENE-2-CARBOXYLIC ACID-->METHYL 3-[(2-BROMOACETYL)AMINO]THIOPHENE-2-CARBOXYLATE-->2,4-DICHLOROTHIENO[3,2-D]PYRIMIDINE-->2,4-Dichlorothieno[3,2-d]pyrimidine-->3-(Acetylamino)thiophene-2-carboxylic acid-->2,4-DIHYDROXYTHIENO[3,2-D]PYRIMIDINE-->3-AMino-4-broMo-thiophene-2-carboxylicacidMethylester

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