4'-Fluoro-2'-hydroxyacetophenone

CAS No.：1481-27-2

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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4'-Fluoro-2'-hydroxyacetophenone Basic information

Product Name:	4'-Fluoro-2'-hydroxyacetophenone
Synonyms:	4'-FLUORO-2'-HYDROXYACETOPHENONE;4-FLUORO-2-HYDROXYACETOPHENONE;4-Fluoro-2-hydroxyacethophenone, 98%;4'-Fluoro-2'-hydroxyacetophenone 98%;4'-Fluoro-2'-hydroxyacetophenone98%;4'-fluoro-2'-hydroxyacetophenone,1-(4-fluoro-2-hydroxyphenyl)ethanone;4-FLUORO-2-HYDROXYACETOPHE;uoro-2'-hydroxyacetophenone
CAS:	1481-27-2
MF:	C8H7FO2
MW:	154.14
EINECS:
Product Categories:	Aromatic Acetophenones & Derivatives (substituted);ketone;Adehydes, Acetals & Ketones;Fluorine Compounds;Phenols;C7 to C8;Carbonyl Compounds;Ketones
Mol File:	1481-27-2.mol

4'-Fluoro-2'-hydroxyacetophenone Chemical Properties

Melting point	32-34°C
Boiling point	65°C 2mm
density	1.1850 (estimate)
Fp	98°C
storage temp.	Inert atmosphere,Room Temperature
pka	9.17±0.10(Predicted)
form	powder to lump
color	White to Almost white
BRN	2249799
InChIKey	HLTBTUXAMVOKIH-UHFFFAOYSA-N
CAS DataBase Reference	1481-27-2(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36/37/39-36
WGK Germany	3
HazardClass	IRRITANT
HS Code	29147000

MSDS Information

Provider	Language
ALFA	English

4'-Fluoro-2'-hydroxyacetophenone Usage And Synthesis

Chemical Properties	Colorless to yellow liquid
Uses	4′-Fluoro-2′-hydroxyacetophenone may be used in the preparation of series of 4′-fluoro-2′-hydroxychalcones, via aldol condensation with substituted aldehydes followed by cyclization with hydrazine hydrate.
Preparation	Preparation by Fries rearrangement of 3-fluorophenyl acetate with aluminium chloride without solvent at 160–180° (75%) (88–90%).
General Description	4′-Fluoro-2′-hydroxyacetophenone is a substituted acetophenone derivative. Biological Baeyer-Villiger oxidation of 4′-fluoro-2′-hydroxyacetophenone to 4-fluorocatechol by using whole cells of Pseudomonas fluorescens ACB has been reported. Its crystals belong to the monoclinic crystal system and space group P2₁/n.

4'-Fluoro-2'-hydroxyacetophenone Preparation Products And Raw materials

Raw materials	2',4'-Difluoroacetophenone-->1-ACETOXY-3-FLUOROBENZENE-->2'-Fluoro-4'-hydroxyacetophenone
Preparation Products	6-Fluoro-3(2H)-benzofuranone

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