(R)-(+)-Glycidol

CAS No.：57044-25-4

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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(R)-(+)-Glycidol Basic information

Product Name:	(R)-(+)-Glycidol
Synonyms:	EOS-60676;(r)-oxiranemethano;(R)-(+)-2,3-EPOXY-1-PROPANOL;(R)-(+)-GLYCIDOL;(R)-GLYCIDOL;R(+)-OXIRANE-2-METHANOL;(R)-Oxiranemethanol;OXIRANEMETHANOL, (2R)-
CAS:	57044-25-4
MF:	C3H6O2
MW:	74.08
EINECS:	404-660-4
Product Categories:	Chiral Compound;CHIRAL COMPOUNDS;chiral;API intermediates
Mol File:	57044-25-4.mol

(R)-(+)-Glycidol Chemical Properties

Boiling point	56-57 °C11 mm Hg(lit.)
density	1.116 g/mL at 20 °C(lit.)
refractive index	n20/D 1.43(lit.)
Fp	178 °F
storage temp.	-20°C
Water Solubility	Completely miscible in water
pka	14.62±0.10(Predicted)
form	neat
color	Colorless to Light yellow
optical activity	[α]23/D +15°, neat
BRN	79782
InChIKey	CTKINSOISVBQLD-GSVOUGTGSA-N
CAS DataBase Reference	57044-25-4(CAS DataBase Reference)
NIST Chemistry Reference	Oxiranemethanol, (R)-(57044-25-4)

Safety Information

Hazard Codes	T,E
Risk Statements	45-60-2-21/22-23-34-68-41-37/38
Safety Statements	53-45-36/37/39-26
RIDADR	UN 2922 8/PG 2
WGK Germany	3
RTECS	RR0508000
F	10-21
HazardClass	6.1
PackingGroup	Ⅲ
HS Code	29109000

MSDS Information

Provider	Language
SigmaAldrich	English

(R)-(+)-Glycidol Usage And Synthesis

Chemical Properties	Colorless to light yellow liqui
Uses	(R)-(+)-Glycidol may be used in the following synthesis: heteroarylpropane-2,3-diols, useful for combinatorial oligomer synthesis enantiomerically pure (2S,3S)- and (2S,3R)-threoninol and -hydroxyphenylalaninol 2-amino-1,4-anhydro-pentitol and 3-amino-1,5-anhydro-4-deoxy-hexitol with the arabino configuration (S)-4-tosyloxymethyl-2-oxazolidinone, required for the synthesis of protected amino alcohol derivatives 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine [(S)-HPMPC] chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product
Uses	(R)-(+)-Glycidol can be used to construct chiral building blocks of epoxyvinyl iodide intermediates in the synthesis of furanocembrane, a marine natural product.
General Description	Enantioselective esterification of (R)-(+)-glycidol with n-butyric acid in organic media using hybrid gel-entrapped lipase on Celite has been reported.
Purification Methods	[S(-)-isomer, § also available on polymer support, has b 49-50o/7mm, 66-67o/19mm, [ ] D -1 5o(neat)], [R(+)-isomer has b 56 -5 6 . 5o/11mm, d 4 1.117, n D 1.429, [ ] D +15o (neat)]. Purify glycidol by fractional distillation.

(R)-(+)-Glycidol Preparation Products And Raw materials

Preparation Products

(S)-(+)-Methyl glycidyl ether-->(S)-(+)-Glycidyl butyrate

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