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| 4-Hydroxybenzylamine Basic information |
| 4-Hydroxybenzylamine Chemical Properties |
| Melting point | 123-128 °C | | Boiling point | 262.4±15.0 °C(Predicted) | | density | 1.141±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | DMSO (Slightly), Water (Slightly, Heated) | | pka | 8.93±0.26(Predicted) | | form | Powder | | color | Off-white to pale yellow | | InChIKey | RQJDUEKERVZLLU-UHFFFAOYSA-N | | CAS DataBase Reference | 696-60-6(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 34-36/37/38 | | Safety Statements | 26-36/37/39-24/25 | | RIDADR | 2735 | | WGK Germany | 3 | | Hazard Note | Irritant | | HazardClass | IRRITANT, CORROSIVE | | HS Code | 29214990 |
| 4-Hydroxybenzylamine Usage And Synthesis |
| Description | 4-HOBA is an isomer of the isoketal scavenger 2-HOBA that has reduced efficacy as an isoketal scavenger. Unlike 2-HOBA, 4-HOBA has no effect on hypertension induced by angiotensin II in mice. 4-HOBA has been used as a negative control for the activity of 2-HOBA and related compounds in a mouse model of hypertension. | | Chemical Properties | 4-Hydroxybenzylamine, also known as tyramine and p-hydroxyphenethylamine, is a white or off-white or light green solid. Tyramine, a compound originally isolated from ergot alkaloids and decomposed animal tissues, is an important synthetic drug intermediate. | | Uses | 4-Hydroxybenzylamine (cas# 696-60-6) is a compound useful in organic synthesis. | | Preparation | Synthesis of 4-Hydroxybenzylamine:Ammonia is passed into 500 ml of ethanol at 10° C. until saturation is reached, 122.1 g=1 mole of p-hydroxybenzaldehyde, 20 g of Raney nickel and 0.1 ml of concentrated sulfuric acid are added and the mixture is stirred in an autoclave for 6 hours at room temperature and under a hydrogen pressure of 100 atmospheres. After releasing the pressure, the catalyst is filtered off and the filtrate is boiled up with active charcoal, filtered and concentrated. The residue is recrystallized from a mixture of ethanol and ether. This gives 104 g (85% of theory), melting point: 104° C.Literature source US04391805 |
| 4-Hydroxybenzylamine Preparation Products And Raw materials |
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