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| HOMOGENTISIC ACID Basic information |
| HOMOGENTISIC ACID Chemical Properties |
| Melting point | 150-152 °C (lit.) | | Boiling point | 257.07°C (rough estimate) | | density | 1.3037 (rough estimate) | | refractive index | 1.5090 (estimate) | | storage temp. | 2-8°C | | solubility | Soluble in methanol. | | pka | 4.4(at 25℃) | | form | crystalline | | color | off-white to tan | | Water Solubility | very faint turbidity | | Merck | 14,4737 | | BRN | 2692860 | | CAS DataBase Reference | 451-13-8(CAS DataBase Reference) | | EPA Substance Registry System | Benzeneacetic acid, 2,5-dihydroxy- (451-13-8) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | RTECS | AH0589000 | | TSCA | Yes | | HS Code | 29182900 |
| HOMOGENTISIC ACID Usage And Synthesis |
| Chemical Properties | off-white to tan crystals or crystalline powder | | Uses | An intermediate in the metabolism of tyrosine and phenylalanine. Occurs in plants and in the urine of alkaptonurics. | | Uses | Homogentisic acid may be used as an analytical reference standard for the quantification of the analyte in the following:- Urine matrices using reversed-phase liquid chromatography tandem mass spectrometry (LC-MS/MS).
- Strawberry tree honey samples using reversed phase-high performance liquid chromatography (RP-HPLC) and ion chromatography (IC).
It may also be used as an internal standard for the determination of ascorbic acid (AA) and uric acid (UA) in human plasma samples using high-pressure liquid chromatography–electrochemical detection (HPLC–ECD). | | General Description | Homogentisic acid (HGA) is an intermediate formed during the catabolism of phenylalanine and tyrosine. Alkaptonuria, a metabolic disorder, is characterized by high levels of HGA in serum and urine due to the deficiency of the enzyme homogentisic acid oxidase, which is involved in the degradation of HGA. | | Purification Methods | Crystallise homogentisic acid from EtOH/CHCl3 or H2O (solubility is 85% at 25o). [Beilstein 10 IV 1506.] |
| HOMOGENTISIC ACID Preparation Products And Raw materials |
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