Other grades of this product :
| Terazosin hydrochloride dihydrate Basic information |
| Product Name: | Terazosin hydrochloride dihydrate | | Synonyms: | arbonyl)-,monohydrochloride,dihydrate;4-Amino-6,7-dimethoxy-2-[4-(tetrahydro-2-furoyl)-1-piperazinyl]quinazoline Hydrochloride;Terazosine Hydrochloride Dihydrate;Methanone,[4-(4-aMino-6,7-diMethoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)-,hydrochloride, hydrate (1:1:2);Terazosin Hydrochloride Impurity Ⅴ;2-chloro-4-amino-6,7-dimethoxyquinazolin;Terazosin Hydrochloride Terazosin hydrochloride IMP | | CAS: | 70024-40-7 | | MF: | C19H30ClN5O6 | | MW: | 459.92 | | EINECS: | 629-697-5 | | Product Categories: | Inhibitors;API;Active Pharmaceutical Ingredients;Antihypertensive | | Mol File: | 70024-40-7.mol |
| Terazosin hydrochloride dihydrate Chemical Properties |
| Melting point | 271-274°C | | storage temp. | Sealed in dry,Room Temperature | | solubility | Sparingly soluble in water, slightly soluble in methanol, very slightly soluble in ethanol (96 per cent), practically insoluble in acetone. | | form | neat | | color | White | | CAS DataBase Reference | 70024-40-7(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 22 | | RTECS | TK8046000 | | HS Code | 2934990002 | | Toxicity | LD50 in male, female rats (mg/kg): 277, 293 i.v. (Fort) |
| Terazosin hydrochloride dihydrate Usage And Synthesis |
| Chemical Properties | White or slightly yellow, crystalline powder. | | Uses | analgesic, antiinflammatory | | Uses | Terazosin Hydrochloride Dihydrate is an α-1-adrenergic blocker related to prazosin. | | Manufacturing Process | To a solution of n-butanol (316 ml), water (24 ml) and N-(2-
tetrahydrofuroyl)piperazine (20 g) were added, while stirring, 4-amino-2-
chloro-6,7-dimethoxyquinazoline (22.2 g). The reaction mixture was heated to
reflux and the reflux was maintained for about 9 h. Then the reaction mixture
was cooled to room temperature and stirred at this temperature for about 10-
12 h. The crystals were collected by filtration, washed with n-BuOH and dried
in vacuo at 40-50°C to yield 40.1 g (94%) of the 1-(4-amino-6,7-dimethoxy-
2-quinazolinyl)-4-(tetrahydrofuroyl)piperazine hydrochloride dihydrate | | Therapeutic Function | Antihypertensive |
| Terazosin hydrochloride dihydrate Preparation Products And Raw materials |
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