METHYL 3-HYDROXY-5-ISOXAZOLECARBOXYLATE

CAS No.：10068-07-2

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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METHYL 3-HYDROXY-5-ISOXAZOLECARBOXYLATE Basic information

Product Name:	METHYL 3-HYDROXY-5-ISOXAZOLECARBOXYLATE
Synonyms:	3-HYDROXYISOXAZOLE-5-CARBOXYLIC ACID*MET HYL ESTER;METHYL 3-OXOOXAZOLE-5-CARBOXYLATE;METHYL 3-HYDROXY-5-ISOXAZOLECARBOXYLATE;METHYL 3-HYDROXYISOXAZOLE-5-CARBOXYLATE;METHYL 3-HYDROXYL-5-ISOXAZOLECARBOXYLATE;Methyl 3-hydroxyisoxazole-5-carboxylate,99%;Methyl 3-hydroxy-1,2-oxazole-5-carboxylate;2,3-DIHYDRO-3-OXO-5-ISOXAZOLECARBOXYLIC ACID, METHYL ESTER
CAS:	10068-07-2
MF:	C5H5NO4
MW:	143.1
EINECS:
Product Categories:	Heterocyclic Compounds;Aromatics Compounds;Aromatics;Intermediates;Building Blocks;Heterocyclic Building Blocks;pharmacetical;Heterocycles series;Isoxazoles
Mol File:	10068-07-2.mol

METHYL 3-HYDROXY-5-ISOXAZOLECARBOXYLATE Chemical Properties

Melting point	160-163 °C(lit.)
Boiling point	261.15°C (rough estimate)
density	1.5918 (rough estimate)
refractive index	1.5820 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform, Ethanol, Ether, Ethyl Acetate, Methanol
form	Powder
pka	11.25±0.40(Predicted)
color	Light Yellow
InChIKey	BBFWUUBQSXVHHZ-UHFFFAOYSA-N
CAS DataBase Reference	10068-07-2(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
HazardClass	IRRITANT
HS Code	29349990

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English

METHYL 3-HYDROXY-5-ISOXAZOLECARBOXYLATE Usage And Synthesis

Chemical Properties	Light Yellow Powder
Uses	An interesting intermediate
Uses	Methyl 3-hydroxy-5-isoxazolecarboxylate was used in the enantioselective synthesis of a key precursor to the tetracycline antibiotics. It was also used in the preparation of formamidinopiperidine analog, an N-amidinopiperidine compound.
Synthesis Reference(s)	Journal of Medicinal Chemistry, 20, p. 965, 1977 DOI: 10.1021/jm00217a023

METHYL 3-HYDROXY-5-ISOXAZOLECARBOXYLATE Preparation Products And Raw materials

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