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| 9-(BETA-D-ARABINOFURANOSYL)GUANINE Basic information |
| Product Name: | 9-(BETA-D-ARABINOFURANOSYL)GUANINE | | Synonyms: | 9-beta-D-Arabinofuranosylguanine Hydrate;2-AMino-9-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one;Arabinoguanosine;Araguanosine;ara-Guanosine;Guanine arabinoside;9-β-D-Arabinofuranosyl guanine hydrate;9-beta-Arabinosylguanine | | CAS: | 38819-10-2 | | MF: | C10H13N5O5 | | MW: | 283.24 | | EINECS: | | Product Categories: | | Mol File: | 38819-10-2.mol |
| 9-(BETA-D-ARABINOFURANOSYL)GUANINE Chemical Properties |
| Melting point | 225°C(lit.) | | density | 2.25±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,2-8°C | | solubility | DMSO: >10mg/mL | | pka | 9?+-.0.20(Predicted) | | form | solid | | color | White to Off-White | | λmax | 252nm(lit.) | | InChIKey | NYHBQMYGNKIUIF-FJFJXFQQSA-N |
| Hazard Codes | Xn | | Risk Statements | 22-36/37/38 | | Safety Statements | 26 | | WGK Germany | 3 | | RTECS | MF8301000 | | HS Code | 29349990 |
| 9-(BETA-D-ARABINOFURANOSYL)GUANINE Usage And Synthesis |
| Description | Ara-G is an analog of the nucleoside guanosine and an active metabolite of nelarabine . Ara-G accumulates in T lymphoblasts and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporated into the DNA. Ara-G inhibits DNA replication by 92% after 30 minutes when used at a concentration of 50 μM in CEM cells, which are used as a model for human T lymphoblasts. It also halts the cell cycle at the sub-G1 phase and induces apoptosis in CEM cells. Syngeneic bone marrow containing 6C3HED tumor cells treated with ara-G (100 mM) ex vivo prior to transplantation increases survival of lethally irradiated mice and induces reconstitution of lymphoid, myeloid, and erythroid cell linages. | | Uses | Ara-G is an inducer of apoptosis, inhibitor of DNA synthesis, an antimetabolite, and antineoplastic. | | Definition | ChEBI: A purine nucleoside in which guanine is attached to arabinofuranose via a beta-N9-glycosidic bond. It inhibits DNA synthesis and causes cell death. |
| 9-(BETA-D-ARABINOFURANOSYL)GUANINE Preparation Products And Raw materials |
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