Closantel

Closantel
  • CAS No.:57808-65-8
Other grades of this product :

Closantel Basic information
Description References
Product Name:Closantel
Synonyms:5-diiodo-y-;benzamide,n-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydrox;faskoverm;CLOSANTEL;CLOSANTEL BASE;N-[5-CHLORO-4-(4-CHLORO-ALPHA-CYANOBENZYL)-2-METHYLPHENYL]-2-HYDROXY-3,5-DIIODOBENZAMIDE;n-[5-chloro-4-[(chlorophenyl)cyannomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamid;iodobenzamide
CAS:57808-65-8
MF:C22H14Cl2I2N2O2
MW:663.07
EINECS:260-967-1
Product Categories:COREG CR
Mol File:57808-65-8.mol
Closantel Chemical Properties
Melting point 217.8°
Boiling point 590.5±50.0 °C(Predicted)
density 1.8759 (estimate)
storage temp. Keep in dark place,Sealed in dry,2-8°C
form neat
pka5.99±0.48(Predicted)
CAS DataBase Reference57808-65-8(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 22
RIDADR 2811
WGK Germany 3
RTECS CV2444250
HazardClass 6.1(b)
PackingGroup III
ToxicityA veterinary drug for the treatment of fluke and nematode infestations. In 1993, some was included in a batch of donated drugs sent to Lithuania. Attempts to match the product with the names of other medicines on accompanying literature resulted in its misidentification as a treatment for endometriosis. Eleven women lost their eyesight; though this has since returned, they were left with eye pain and are unable to work.
MSDS Information
ProviderLanguage
N-[5-Chloro-4-[(chlorophenyl)cyannomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamidEnglish
Closantel Usage And Synthesis
DescriptionClosantel is a kind of synthetic anti parasitic agent which is actively against liver fluke, bloodsucking nematodes and larval stages of some arthropods in sheep and cattle. Its mechanism of action is through decoupling the mitochondrial oxidative phosphorylation, thus inhibiting the production of ATP. Therefore, it inhibit their energy generation of the parasite, causing their death. It is mainly used for the treatment and prevention of several infections caused by many kinds of parasites such as Fasciola hepatica, Fasciola gigantica, Haemonchus concortus, Haemonchus placei, Bunostomum phlebotomum, Oesophagostomum radiatum and Strongyloides papillosus in cattle and sheep.
Referenceshttp://www.interchemie.com/veterinary-medicines/closan-50.html
Chemical PropertiesWhite to light yellow powder
Usesantianginal, antihypertensive
Closantel Preparation Products And Raw materials

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