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| 2,4-DIFLUOROPYRIMIDINE Basic information | | Synthesis |
| Product Name: | 2,4-DIFLUOROPYRIMIDINE | | Synonyms: | 2,4-DIFLUOROPYRIMIDINE;NSC 331813;EOS-61621;Pyrimidine, 2,4-difluoro- (6CI,8CI,9CI);2,4-Difluoropyrimidine 98%;2,4-Difluoropyrimidine98%;Pyrimidine, 2,4-difluoro-;2,4-DIFLUOROPYRIMIDINE ISO 9001：2015 REACH | | CAS: | 2802-61-1 | | MF: | C4H2F2N2 | | MW: | 116.07 | | EINECS: | 631-074-8 | | Product Categories: | PYRIMIDINE;Halides;Pyrazines, Pyrimidines & Pyridazines;Heterocyclic Compounds;Pyrazines, Pyrimidines & Pyridazines;Building Blocks;Heterocyclic Building Blocks;Pyrimidines | | Mol File: | 2802-61-1.mol |
| 2,4-DIFLUOROPYRIMIDINE Chemical Properties |
| Boiling point | 118-120 °C | | density | 1.359 g/mL at 25 °C | | refractive index | n20/D 1.432 | | Fp | 106 °F | | pka | -2.52±0.20(Predicted) | | CAS DataBase Reference | 2802-61-1(CAS DataBase Reference) |
| Hazard Codes | Xn,Xi | | Risk Statements | 10-22-37/38-41 | | Safety Statements | 26-39 | | RIDADR | UN 1993 3/PG 3 | | WGK Germany | 3 | | Hazard Note | Irritant | | HazardClass | 3 | | PackingGroup | III | | HS Code | 29335990 |
| 2,4-DIFLUOROPYRIMIDINE Usage And Synthesis |
| Synthesis | Crown ethers are able to enhance the performance of KF in two ways. Firstly,
they complex the potassium cation making a better fluoride source and secondly they
increase the solubility of KF in the solvent.
KF with a catalytic amount of dicyclohexano-18-crown-6 in tetraglyme converted
2,4-dichloropyrimidine into 2,4-difluoropyrimidine. | | Uses | 2,4-Difluoropyrimidine can be used as a starting material to synthesize: - 3-Pyrimidin-4-yl-oxazolidin-2-one derivatives as mutant isocitrate dehydrogenase (IDH1) inhibitors.
- N,N′-(1,4-phenylenebis(methylene))bis(2-fluoropyrimidin-4-amine) as chemokine receptor type 4 antagonists.
| | Synthesis Reference(s) | Journal of Heterocyclic Chemistry, 22, p. 149, 1985 DOI: 10.1002/jhet.5570220137 |
| 2,4-DIFLUOROPYRIMIDINE Preparation Products And Raw materials |
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