| Methacetin Basic information |
| Product Name: | Methacetin |
| Synonyms: | p-Acetanasidine~N-(Methoxyphenyl)acetamide;p-Acetanasidine;p-Acetoanisidide;4'-Methoxyacetanilide, 99+%;n-(methoxyphenyl)acetamide;p-acetaniside;acetaniside;p-acetylanisidine |
| CAS: | 51-66-1 |
| MF: | C9H11NO2 |
| MW: | 165.19 |
| EINECS: | 200-114-2 |
| Product Categories: | Intermediates of Dyes and Pigments;Anilines, Amides & Amines;Anisoles, Alkyloxy Compounds & Phenylacetates;Aromatics;Diagnostic |
| Mol File: | 51-66-1.mol |
| Methacetin Chemical Properties |
| Melting point | 128-130 °C(lit.) |
| Boiling point | 293.03°C (rough estimate) |
| density | 1.1603 (rough estimate) |
| refractive index | 1.5839 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Crystalline |
| pka | 14.53±0.70(Predicted) |
| color | White |
| Water Solubility | 0.42 g/100 mL (20 ºC) |
| Merck | 14,51 |
| BRN | 387887 |
| CAS DataBase Reference | 51-66-1(CAS DataBase Reference) |
| NIST Chemistry Reference | N-(4-Methoxyphenyl)acetic acid amide(51-66-1) |
| EPA Substance Registry System | Acetamide, N-(4-methoxyphenyl)- (51-66-1) |
| Safety Information |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36/38 |
| Safety Statements | 36-37/39-26 |
| WGK Germany | 1 |
| RTECS | AE8290000 |
| TSCA | Yes |
| HS Code | 29242990 |
| Toxicity | LD50 orl-mus: 1190 mg/kg TXAPA9 19,20,71 |
| MSDS Information |
| Provider | Language |
|---|---|
| N-(4-Methoxyphenyl)acetamide | English |
| ACROS | English |
| SigmaAldrich | English |
| ALFA | English |
| Methacetin Usage And Synthesis |
| Chemical Properties | LIGHT BEIGE CRYSTALLINE POWDER |
| Uses | Methacetin is evaluated in a breath test to predict early liver disfunction due to valproic acid and other cause. Methacetin breath test (MBT) is a rapid, non-invasive assessment of liver function in acute severe liver disease and a potential key tool in future dignosis. |
| Synthesis Reference(s) | Journal of the American Chemical Society, 89, p. 7131, 1967 DOI: 10.1021/ja01002a061The Journal of Organic Chemistry, 42, p. 3755, 1977Organic Syntheses, Coll. Vol. 3, p. 661, 1955 |
| Safety Profile | Moderately toxic by ingestion andother unspecified routes. When heated to decomposition itemits toxic fumes of NOx. |
| Methacetin Preparation Products And Raw materials |
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