N-Methylolchloroacetamide

CAS No.：2832-19-1

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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N-Methylolchloroacetamide Basic information

Product Name:	N-Methylolchloroacetamide
Synonyms:	2-chloro-N-(hydroxymethyl)acetamid;2-chloro-n-(hydroxymethyl)-acetamid;2-chloro-n-hydroxymethyl-acetamid;chloracetamide-n-metholol;n-methylol-chloracetamide;2-CHLORO-N-(HYDROXYMETHYL)ACETAMIDE;N-METHYLOLCHLOROACETAMIDE;N-HYDROXYMETHYL-2-CHLOROACETAMIDE
CAS:	2832-19-1
MF:	C3H6ClNO2
MW:	123.54
EINECS:	220-598-9
Product Categories:	Amides;Carbonyl Compounds;Organic Building Blocks
Mol File:	2832-19-1.mol

N-Methylolchloroacetamide Chemical Properties

Melting point	100-105 °C(lit.)
Boiling point	374.0±27.0 °C(Predicted)
density	1.2776 (rough estimate)
refractive index	1.5000 (estimate)
storage temp.	Inert atmosphere,2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
pka	12.63±0.46(Predicted)
form	Solid
color	White to Off-White
Water Solubility	Very soluble in water. Poorly soluble in aliphatic hydrocarbons.
Sensitive	Hygroscopic
BRN	1811765
CAS DataBase Reference	2832-19-1(CAS DataBase Reference)
EPA Substance Registry System	2-Chloro-N-(hydroxymethyl)acetamide (2832-19-1)

Safety Information

Hazard Codes	C
Risk Statements	34-43-40-20/21/22
Safety Statements	26-27-36/37/39-45
RIDADR	UN 3261 8/PG 2
WGK Germany	3
RTECS	AB5733000
TSCA	Yes
HazardClass	8
PackingGroup	Ⅱ
HS Code	29241990

MSDS Information

Provider	Language
2-Chloro-N-(hydroxymethyl)acetamide	English
SigmaAldrich	English
ACROS	English
ALFA	English

N-Methylolchloroacetamide Usage And Synthesis

Chemical Properties	White or almost white crystalline powder
Uses	N-Methylolchloro-acetamide is a preservative in cooling fluids and cosmetics.
Uses	An organic building block. It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals. As dyestuff intermediate .
Uses	2-Chloro-N-(hydroxymethyl)acetamide (N-hydroxymethylchloroacetamide) may be used as a reagent in the synthesis of 1-(aminomethyl)-2-methoxynaphthalene hydrochloride and as a amidomethylating reagent for N,N-dialkylanilines (Tscherniac-Einhorn reaction).
General Description	2-Chloro-N-(hydroxymethyl)acetamide (N-methylolchloracetamide) is a N-hydroxymethyl derivative of chloroacetamide. One of the method reported for its synthesis is by the reaction of 2-chloracetamide with formaldehyde. It has been reported to be a formaldehyde releaser and an infrequent sensitizer to formaldehyde contact allergy. Influence of short and prolonged exposure of 2-chloro-N-(hydroxymethyl)acetamide (as formaldehyde donor/releaser) on lymph node responses has been investigated. It has high biocide action and is utilized as preservative.

N-Methylolchloroacetamide Preparation Products And Raw materials

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