2,4-Thiazolidinedione

CAS No.：2295-31-0

Other grades of this product :

2,4-Thiazolidinedione Basic information

Product Name:	2,4-Thiazolidinedione
Synonyms:	2,4-Thiazolidinedione, 99% 100GR;2,4-Thiazolidinedione, 99% 25GR;thiazolidin-2,4-dione;2,4-Thiazolidinedione technical grade, 90%;2, 4 - Margaret diketone;OTAVA-BB BB7112440002;TZD;TIMTEC-BB SBB000047
CAS:	2295-31-0
MF:	C3H3NO2S
MW:	117.13
EINECS:	218-941-2
Product Categories:	Starting Raw Materials & Intermediates;PHARMACEUTICAL INTERMEDIATES;Sulfur compounds;blocks;Heterocycles;Sulphur Derivatives;Thiazoles;Drug Intermediates;(intermedate of rosiglitazone);All Inhibitors;Diabetes;Inhibitors;Ring Systems;Building Blocks;Heterocyclic Building Blocks;bc0001
Mol File:	2295-31-0.mol

2,4-Thiazolidinedione Chemical Properties

Melting point	125-127 °C (lit.)
Boiling point	178-179 °C (19 mmHg)
density	1.408 (estimate)
vapor pressure	0Pa at 25℃
refractive index	1.5130 (estimate)
Fp	178-179°C/19mm
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Crystalline Powder
pka	6.50±0.10(Predicted)
color	Slightly yellow
Water Solubility	Soluble in water (30 mg/ml at 3°C), methanol, DMSO, ethanol, and ethyl ether.
BRN	110700
InChIKey	ZOBPZXTWZATXDG-UHFFFAOYSA-N
LogP	-0.29 at 25℃
CAS DataBase Reference	2295-31-0(CAS DataBase Reference)
NIST Chemistry Reference	2,4-Thiazolidinedione(2295-31-0)
EPA Substance Registry System	2,4-Thiazolidinedione (2295-31-0)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	24/25-36-26
WGK Germany	3
RTECS	XJ5775000
TSCA	Yes
HazardClass	IRRITANT
HS Code	29341000

MSDS Information

Provider	Language
Thiazolidine-2,4-dione	English
ACROS	English
SigmaAldrich	English
ALFA	English

2,4-Thiazolidinedione Usage And Synthesis

Chemical Properties	White to Off-White Powder
Uses	Inhibitor of enzyme
Uses	2,4-Thiazolidinedione may be used in the synthesis of sixteen 5-arylidene-2,4-thiazolidinediones, via ultrasound-promoted aldol condensation reaction. It may be used as starting material for the synthesis of drugs with antihyperglycemic activity.
Definition	ChEBI: A thiazolidenedione carrying oxo substituents at positions 2 and 4.
General Description	2,4-Thiazolidinedione is a well-known peroxisome proliferator-activated receptors (PPAR) activator. Its effect on aging process using kidneys from Fischer 344 rats has been reported. A library of conjugates of 2,4-thiazolidinedione has been synthesized by Knoevenagel condensation followed by reduction using hydrogen gas and Pd/C catalyst. Knoevenagel condensation of various aromatic aldehydes with 2,4-thiazolidinedione in polyethylene glycol-300 has been reported.
Flammability and Explosibility	Notclassified

2,4-Thiazolidinedione Preparation Products And Raw materials

Raw materials	Rhodanine
Preparation Products	Thiazole-5-carboxaldehyde-->Thiazole-4-carboxaldehyde-->Rosiglitazone-->2,4-Dibromothiazole-->S49076-->2,4-DIBROMO-THIAZOLE-5-CARBALDEHYDE,97%-->(2,4-DIOXO-1,3-THIAZOLIDIN-3-YL)ACETIC ACID-->2,4-Dichlorothiazole-->5-{4-[2-(5-Ethyl-2-pyridinyl)ethoxyl]benzyldene}-2,4-thiazolidinedione-->2,4-Dichloro-5-thiazolecarboxaldehyde

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