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| 2-Indanone Chemical Properties |
| Melting point | 51-54 °C (lit.) | | Boiling point | 218°C | | density | 1.0712 | | refractive index | 1.5380 (estimate) | | Fp | 212 °F | | storage temp. | 2-8°C | | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) | | form | Crystals or Powder | | color | Light yellow to yellow-brown | | Odor Threshold | 0.00036ppm | | Water Solubility | insoluble | | Sensitive | Hygroscopic | | BRN | 636550 | | InChIKey | UMJJFEIKYGFCAT-UHFFFAOYSA-N | | CAS DataBase Reference | 615-13-4(CAS DataBase Reference) | | NIST Chemistry Reference | 2H-inden-2-one, 1,3-dihydro-(615-13-4) | | EPA Substance Registry System | 2-Indanone (615-13-4) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 22-24/25-36-26 | | WGK Germany | 3 | | RTECS | NK7535500 | | F | 3 | | Hazard Note | Irritant | | TSCA | Yes | | HS Code | 29145090 |
| 2-Indanone Usage And Synthesis |
| Uses | 2-Indanone is an indanone with an oxo substituent at position 2. It is a metabolite of indane. It has a role as a xenobiotic metabolite. 2-Indanone is an intermediate for the preparation of aprindine hydrochloride and ceforanide. It is an important intermediate in organic synthesis.
| | Preparation | 2-Indanone is prepared by using acetic acid as solvent, acetic anhydride as catalyst and through hydrogen peroxide oxidation into 1, 2-indenediol, which reacted with dilute sulfuric acid solution in order to obtain crude 2-indanone. Finally, vacuum sublimation to obtain 2-indanone with high-purity, the total yield is 89%.
| | Chemical Properties | Wet crystalline aggregates | | Uses | 2-Indanone undergoes TiCl4-Mg mediated coupling with CHBr3 to yield dibromomethyl carbinol. It reacts with 5,5-dimethyl-3-pyrazolidinone to yield 5,5-dimethyl-2-(1H-indenyl-2)-3-pyrazolidinone. On photolysis by 266-nm one-photon excitation yields o-xylylene. It was used as starting reagent in the synthesis of indene-fused porphyrins. | | Definition | ChEBI: An indanone with an oxo substituent at position 2. It is a metabolite of indane. | | Synthesis Reference(s) | Chemistry Letters, 11, p. 325, 1982Organic Syntheses, Coll. Vol. 5, p. 647, 1973Tetrahedron Letters, 15, p. 3789, 1974 DOI: 10.1016/S0040-4039(01)92010-6 | | General Description | 2-Indanone undergoes TiCl4-Mg mediated coupling with CHBr3 to yield dibromomethyl carbinol. It reacts with 5,5-dimethyl-3-pyrazolidinone to yield 5,5-dimethyl-2-(1H-indenyl-2)-3-pyrazolidinone. 2-Indanone on photolysis by 266-nm one-photon excitation yields o-xylylene. |
| 2-Indanone Preparation Products And Raw materials |
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