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| Methyl isonipecotate Basic information |
| Methyl isonipecotate Chemical Properties |
| Boiling point | 85-90 °C (lit.) | | density | 1.06 g/mL at 25 °C (lit.) | | refractive index | 1.465 | | Fp | 192°F | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | solubility | Chloroform | | form | Liquid | | pka | 9.78±0.10(Predicted) | | color | Colorless to yellow | | Water Solubility | Slightly soluble in water. | | CAS DataBase Reference | 2971-79-1(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | RIDADR | 3267 | | WGK Germany | 3 | | HS Code | 29333990 |
| Methyl isonipecotate Usage And Synthesis |
| Chemical Properties | Colorless liquid | | Uses | Methyl piperidine-4-carboxylate is a reactant for C-2 arylation of piperidines through directed transition metal-catalyzed sp3 C-H activation. It is used as a reactant for synthesis of antitubercular agents, aminopyrazine inhibitors, orally available naphthyridine protein kinase D inhibitors and a scalable catalyst from asymmetric hydrogenation of sterically demanding aryl enamide. | | Uses | Methyl isonipecotate may be used for the synthesis of a series of potent non-urea soluble epoxide hydrolase (sEH) inhibitors via high throughput screens. | | Uses | 4-Piperidinecarboxylic acid methyl ester is a an ester derivative of 4-piperidinecarboxylic acid used as a reagent in the organic synthesis of neurochemicals, antibacterials and other biologically active compounds.
| | General Description | Methyl isonipecotate can be obtained by the reduction of methyl isonicotinate in methanol with ruthenium at 100-150°C. |
| Methyl isonipecotate Preparation Products And Raw materials |
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