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| L-KYNURENINE Basic information |
| L-KYNURENINE Chemical Properties |
| Melting point | 219 °C | | Boiling point | 466.6±45.0 °C(Predicted) | | density | 1.343±0.06 g/cm3(Predicted) | | refractive index | -33 ° (C=0.4, H2O) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | Soluble in DMSO (up to 2 mg/ml) or in Water (up to 2 mg/ml). | | form | crystalline | | pka | 2.21±0.23(Predicted) | | color | light yellow | | Merck | 14,5328 | | Stability: | Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months. | | InChIKey | YGPSJZOEDVAXAB-QMMMGPOBSA-N | | CAS DataBase Reference | 2922-83-0(CAS DataBase Reference) |
| WGK Germany | 3 | | RTECS | CY9049700 | | HS Code | 2922500090 |
| L-KYNURENINE Usage And Synthesis |
| Description | Kynurenine (2922-83-0) is a tryptophan catabolite.1?Endogenous tumor-promoting ligand of the human aryl hydrocarbon receptor (AhR). Constitutively generated by human tumor cells via the action of the tryptophan degrading enzyme, tryptophan-2,3-dioxygenase (TDO). Kynurenine suppresses antitumor immune responses and promotes tumor cell survival and motility.2 | | Uses | L-Kynurenine has been used as a standard for indoleamine-2,3-dioxygenase (IDO) assay. It has also been used as a standard to extract and quantify kynurenine from cultured cells and media. | | Definition | ChEBI: A kynurenine that has L configuration. | | Biochem/physiol Actions | Key intermediate in the breakdown pathway of tryptophan. | | References | References/Citations
1) Ibana?et al. (2011),?Inhibition of indoleamine 2,3-dioxygenase activity by levo-1-methyl tryptophan blocks gamma interferon-induced Chlaydia trachomatis persistence in human epithelial cells; Infect. Immun.,?79?4425
2) Opitz?et al. (2011),?An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor; Nature,?478?197 |
| L-KYNURENINE Preparation Products And Raw materials |
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