Other grades of this product :
| MMP-2/MMP-9 INHIBITOR IV Basic information |
| Product Name: | MMP-2/MMP-9 INHIBITOR IV | | Synonyms: | SB-3CT;MMP-2/MMP-9 INHIBITITOR IV;MMP-2/MMP-9 INHIBITOR IV;2-[[(4-phenoxyphenyl)sulfonyl]methyl]-thiirane;[[(4-Phenoxyphenyl)sulfonyl]methyl]thiirane;SB-3CT (This product is only available in Japan.);CS-860;MMP-2/MMP-9 Inhibitor IV - CAS 292605-14-2 - Calbiochem | | CAS: | 292605-14-2 | | MF: | C15H14O3S2 | | MW: | 306.4 | | EINECS: | | Product Categories: | Inhibitors | | Mol File: | 292605-14-2.mol |
| MMP-2/MMP-9 INHIBITOR IV Chemical Properties |
| Melting point | 92-96°C | | storage temp. | -20°C | | solubility | DMSO: >20mg/mL | | form | powder | | color | white to off-white |
| Hazard Codes | Xi | | Risk Statements | 36 | | Safety Statements | 26 | | WGK Germany | 3 | | HS Code | 29349990 |
| MMP-2/MMP-9 INHIBITOR IV Usage And Synthesis |
| Uses | SB 3CT is a selective and potent gelatinase inhibitor which may be used for the treatment of brain metastasis. | | Uses | SB?3CT has been used as irreversible inhibitor of matrix metallopeptidase 9 (MMP9) in cell cultures to exclude reciprocal regulation. | | Biochem/physiol Actions | SB-3CT is a potent matrix metalloproteinase MMP-2 and MMP-9 inhibitor. Matrix metalloproteinases (MMPs) are involved in a number of activities including angiogenesis and embryogenesis. In particular, gelatinases A (MMP-2) and B (MMP-9), are thought to facilitate tumor metastasis. SB-3CT exhibits a covalent mechanism based behavior in inhibition of MMP-2 and MMP-9. This inhibitor appears to have similarity to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. SB-3CT has been shown to directly bind to the zinc in the catalytic site of MMP-2. SB-3CT does not affect the activities of MMP-1 (Ki = 206 μM) MMP-3 (Ki = 15 μM), or MMP-7 (Ki = 96 μM). |
| MMP-2/MMP-9 INHIBITOR IV Preparation Products And Raw materials |
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