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| AHU-377 (heMicalciuM salt) Basic information |
| Product Name: | AHU-377 (heMicalciuM salt) | | Synonyms: | AHU-377 (heMicalciuM salt);(alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt (2:1);(2S,4R)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester,calcium salt(2:1);AHU-377 hemicalcium salt (2:1);Calciumbis(4-{[(1S,3R)-1-([1,1'-biphenyl]-4-ylmethyl)-4-ethoxy-3-methyl-4-oxobutyl] amino} -4-oxobutanoate);LCZ696(valsartan + sacubitril) impurity 1;Ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoate hemicalcium salt;(alphar | | CAS: | 1369773-39-6 | | MF: | C48H56CaN2O10 | | MW: | 861.04364 | | EINECS: | 935-847-3 | | Product Categories: | Intermediates;LCZ 696;lcz696;Pharmaceutical Intermediates | | Mol File: | 1369773-39-6.mol |
| AHU-377 (heMicalciuM salt) Chemical Properties |
| Melting point | >140°C (dec.) | | density | 1.24g/cm3 at 20℃ | | vapor pressure | 0.001Pa at 20℃ | | storage temp. | -20°C | | solubility | DMSO (Slightly, Heated), Methanol (Slightly) | | form | powder | | color | white to beige | | LogP | -0.66-2.9 at 20℃ and pH2-7 |
| RIDADR | UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all |
| AHU-377 (heMicalciuM salt) Usage And Synthesis |
| Uses | Sacubitril is an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure. | | Biochem/physiol Actions | Sacubitril (AHU377) is a prodrug inhibitor of the membrane metallo-endopeptidase neprilysin. Sacubitril forms half of the heart failure combination drug LCZ696, along with the angiotensin-receptor blocker Valsartan. Sacubitril (AHU377) is cojnverted by esterases into the active inhibitor LBQ657, which prevents neprilysin′s degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides. The AHU377 valsartan combination drug LCZ696 showed a reduction in the risk of cardiovascular death of 20% compared to the standard ACE inhibitor enalapril, and also a 21% drop in the risk of hospitalization. |
| AHU-377 (heMicalciuM salt) Preparation Products And Raw materials |
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