3,4-Dihydroxyphenylacetic acid

CAS No.：102-32-9

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3,4-Dihydroxyphenylacetic acid Basic information

Product Name:	3,4-Dihydroxyphenylacetic acid
Synonyms:	Ba 2773;DIHYDROXYPHENYLACETIC ACID, 3,4-(RG);Dopac/(3,4-dihydroxyphenyl)-aceticaci;Hypoxanthine DisodiuM;(3,4-dihydroxyphenyl)-aceticaci;3,4-Dihydroxybenzeneacetic acid;3,4-dihydroxy-benzeneaceticaci;3,4-dihydroxybenzeneaceticacid
CAS:	102-32-9
MF:	C8H8O4
MW:	168.15
EINECS:	203-024-1
Product Categories:	buildingblock;Aromatic Phenylacetic Acids and Derivatives
Mol File:	102-32-9.mol

3,4-Dihydroxyphenylacetic acid Chemical Properties

Melting point	127-130 °C (lit.)
Boiling point	257.07°C (rough estimate)
density	1.3037 (rough estimate)
refractive index	1.5090 (estimate)
storage temp.	Inert atmosphere,Room Temperature
solubility	water: soluble50mg/mL, clear, almost colorless
pka	4.42±0.10(Predicted)
form	Powder, Crystals or Lumps
color	White to off-white
Water Solubility	Soluble in water and methanol.
BRN	2211017
CAS DataBase Reference	102-32-9(CAS DataBase Reference)
NIST Chemistry Reference	Acetic acid, (3,4-dihydroxyphenyl)-,(102-32-9)
EPA Substance Registry System	3,4-Dihydroxyphenylacetic acid (102-32-9)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
RTECS	AH0590000
F	10-23
HS Code	29182900

MSDS Information

Provider	Language
DOPAC	English
SigmaAldrich	English
ACROS	English
ALFA	English

3,4-Dihydroxyphenylacetic acid Usage And Synthesis

Description	3,4-Dihydroxyphenylacetic acid (DOPAC) is a metabolite of the neurotransmitter dopamine. Dopamine can be metabolized into one of three substances. One such substance is DOPAC. Another is 3-methoxytyramine (3-MT). Both of these substances are degraded to form homovanillic acid (HVA). Both degradations involve the enzymes monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT), albeit in reverse order: MAO catalyzes dopamine to DOPAC, and COMT catalyzes DOPAC to HVA; whereas COMT catalyzes dopamine to 3-MT and MAO catalyzes 3-MT to HVA. The third metabolic end-product of dopamine is norepinephrine (noradrenaline).DOPAC can be oxidized by hydrogen peroxide, leading to the formation of toxic metabolites which destroy dopamine storage vesicles in the substantia nigra. This may contribute to the failure of levodopa treatment of Parkinson's disease. A MAO-B inhibitor such as selegiline or rasagiline can prevent this from happening.wikipedia
Chemical Properties	beige to light brown crystalline powder
Uses	3,4-Dihydroxyphenylacetic Acid is a metabolite of Dopamine (D533782).
Uses	3,4-Dihydroxyphenylacetic acid is an important metabolite when studying the behavior of the dopaminergic system.
General Description	3,4-dihydroxyphenylacetic acid (DOPAC) is a normal constituent of rat brain tissue. A mass fragmentographic method for determination of DOPAC in rat brain tissue has been described. It is major metabolite of dopamine (DA). The voltammetric reduction of DOPAC has been studied at a glassy carbon electrode modified with single-wall carbon nanotubes (SWNTs). Semi-automatic fluorometric assay technique for DOPAC has been reported.

3,4-Dihydroxyphenylacetic acid Preparation Products And Raw materials

Raw materials

Sodium hydroxide-->Hydrochloric acid-->Sodium carbonate-->Magnesium sulfate-->Acetic anhydride-->Benzene-->Hydrogen peroxide-->Sodium acetate-->Veratraldehyde-->Hippuric acid-->3-(3,4-dihydroxyphenyl)-2-hydroxy-propanoic acid-->3,4-Dihydroxyacetophenone-->Veratraldehyde cyanohydrin-->2-hydroxy-3-(4-hydroxy-3-methoxy-phenyl)-propanoic acid-->4-HYDROXY-3-NITROPHENYLACETIC ACID-->(3,4-DIHYDROXYPHENYL)ACETONITRILE

Preparation Products

3,4-Dihydroxyphenylethanol-->3,4-(METHYLENEDIOXY)PHENYLACETIC ACID-->3,4-DIHYDROXYPHENYLACETAMIDE

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