| L-Menthol Basic information |
| Product Name: | L-Menthol |
| Synonyms: | (1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol;(1r,3r,4s)-(-)-mentho;(1R,3R,4S)-(-)-MENTHOL;(R)-(-)-Menthol;Emtricitabine Impurity 31;Natural Menthol Crystal;L-Meng alcohol Natural menthol Menthol (L);DL-Menthol menthol crystal extract |
| CAS: | 2216-51-5 |
| MF: | C10H20O |
| MW: | 156.27 |
| EINECS: | 218-690-9 |
| Product Categories: | Inhibitors;Organics;chiral;Biochemistry;Terpenes;API;Terpenes (Others);for Resolution of Acids;Monocyclic Monoterpenes;Optical Resolution;Synthetic Organic Chemistry;2216-51-5 |
| Mol File: | 2216-51-5.mol |
| L-Menthol Chemical Properties |
| Melting point | 41-45 °C (lit.) |
| alpha | -51 º (589nm, c=10, EtOH) |
| Boiling point | 212 °C (lit.) |
| density | 0.89 g/mL at 25 °C (lit.) |
| vapor pressure | 0.8 mm Hg ( 20 °C) |
| refractive index | 1.46 |
| FEMA | 2665 | MENTHOL RACEMIC |
| Fp | 200 °F |
| storage temp. | Store below +30°C. |
| solubility | 490mg/l |
| form | Crystals or Crystalline Needles |
| pka | 15.30±0.60(Predicted) |
| Specific Gravity | 0.89 |
| color | Colorless to white |
| optical activity | [α]22/D 49°, c = 10 in 95% ethanol |
| Water Solubility | insoluble |
| Merck | 14,5837 |
| BRN | 1902293 |
| Stability: | Stable. |
| InChIKey | NOOLISFMXDJSKH-KXUCPTDWSA-N |
| LogP | 3.15 at 25℃ |
| CAS DataBase Reference | 2216-51-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Cyclohexanol, 5-methyl-2-(1-methylethyl)-, [1R-(1«alpha»,2«beta»,5«alpha»)]-(2216-51-5) |
| EPA Substance Registry System | Levomenthol (2216-51-5) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 37/38-41-36/37/38 |
| Safety Statements | 26-39-37/39-36 |
| WGK Germany | 2 |
| RTECS | OT0700000 |
| TSCA | Yes |
| HS Code | 29061100 |
| Hazardous Substances Data | 2216-51-5(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: 3300 mg/kg LD50 dermal Rabbit > 5000 mg/kg |
| MSDS Information |
| Provider | Language |
|---|---|
| (1R,2S,5R)-(-)-Menthol | English |
| SigmaAldrich | English |
| ACROS | English |
| ALFA | English |
| L-Menthol Usage And Synthesis |
| Chemical Properties | white to light yellow crystal powde |
| Uses | analgesic (topical), antipruritic agent |
| Uses | (1R,2S,5R)-(-)-Menthol (L-Menthol) is the natural form of Menthol. L-Menthol is used as: refreshing agent, food flavor, cool and antipruritic drug, carminative drug. Menthol crystals is used for pers onal care and cosmetics. |
| Uses | L-Menthol is used as a cooling agent that strongly activates TRPM8.(Transient Receptor Potential Cation Channel, Subfamily M, Member 8 is a Protein Coding gene). It is used as analgesic (topical), antipruritic agent. It is used as: refreshing agent, food flavor, cool and antipruritic drug, carminative drug. Menthol crystals is used for pers onal care and cosmetics. |
| Definition | ChEBI: A p-menthan-3-ol which has (1R,2S,5R)-stereochemistry. It is the most common naturally occurring enantiomer. |
| General Description | Produced and qualified by HWI pharma services GmbH.Exact content by quantitative NMR can be found on the certificate. |
| Flammability and Explosibility | Nonflammable |
| Biochem/physiol Actions | Taste at 25 ppm |
| Safety Profile | Poison by intravenous route. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. An eye irritant. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. |
| Purification Methods | Crystallise menthol from CHCl3,pet ether or EtOH/water. [Barrow & Atkinson J Chem Soc 638 1939, Beilstein 6 III 133, 6 IV 150.] |
| L-Menthol Preparation Products And Raw materials |
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