Other grades of this product :
| 5-Fluoroindole Basic information |
| 5-Fluoroindole Chemical Properties |
| Melting point | 45-48 °C (lit.) | | Boiling point | 120 °C / 1mmHg | | density | 1.1203 (estimate) | | Fp | >230 °F | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Crystalline Powder | | pka | 16.16±0.30(Predicted) | | color | Off-white | | BRN | 112350 | | CAS DataBase Reference | 399-52-0(CAS DataBase Reference) | | NIST Chemistry Reference | 1H-indole, 5-fluoro-(399-52-0) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | F | 10 | | HazardClass | IRRITANT | | HS Code | 29339900 |
| 5-Fluoroindole Usage And Synthesis |
| Chemical Properties | off-white crystalline powder | | Uses | • ;Reactant for preparation of 5-HT6 receptor ligands1• ;Reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators2• ;Reactant for preparation of antitumor agents3• ;Reactant for preparation of antibacterial agents4• ;Reactant for preparation of immunosuppressive agents5• ;Reactant for preparation of Sodium-Dependent Glucose Co-transporter 2 (SGLT2) Inhibitors for the Management of Hyperglycemia in Diabetes6• ;Reactant for preparation of Myeloperoxidase Inhibitors7• ;Reactant fo | | Uses | 5-Fluoroindole is a reactant used in various syntheses. It was used in the synthesis of Spirotetrahydro β-Carbolines (Spiroindolones), which is a new class of potent and orally efficacious compounds for the treatment of malaria. 5-Fluoroindole was also a reactant in direct indole and pyrrole couplings to carbonyl compound in total synthesis of Acremoauxin A and Oxazinin 3. | | Uses | - Reactant for preparation of 5-HT6 receptor ligands
- Reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators
- Reactant for preparation of antitumor agents
- Reactant for preparation of antibacterial agents
- Reactant for preparation of immunosuppressive agents
- Reactant for preparation of Sodium-Dependent Glucose Co-transporter 2 (SGLT2) Inhibitors for the Management of Hyperglycemia in Diabetes
- Reactant for preparation of Myeloperoxidase Inhibitors
- Reactant for preparation of Potent Selective Serotonin Reuptake Inhibitors
| | Definition | ChEBI: An organofluorine compound that is the 5-fluoro derivative of indole. |
| 5-Fluoroindole Preparation Products And Raw materials |
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