Other grades of this product :
| Indazole Basic information |
| Indazole Chemical Properties |
| Melting point | 145-148 °C (lit.) | | Boiling point | 270 °C/743 mmHg (lit.) | | density | 1.4220 (rough estimate) | | refractive index | 1.5500 (estimate) | | Fp | 270°C | | storage temp. | Inert atmosphere,Room Temperature | | pka | 14.00±0.10(Predicted) | | form | Needle-Like Crystalline Powder | | color | White to beige | | Water Solubility | SOLUBLE IN HOT WATER | | Merck | 14,4936 | | BRN | 109676 | | CAS DataBase Reference | 271-44-3(CAS DataBase Reference) | | NIST Chemistry Reference | 1H-Indazole(271-44-3) | | EPA Substance Registry System | Indazole (271-44-3) |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | NK7745000 | | HS Code | 29339990 |
| Indazole Usage And Synthesis |
| Chemical Properties | white to beige needle-like crystalline powder | | Uses | 1H-Indazole is used in organic synthesis, it can react with butyryl chloride and 1-butyryl-1H-indazole. It is also used in synthesis of several small molecule inhibitors as potential cancer therapeutics. | | Synthesis Reference(s) | Journal of the American Chemical Society, 79, p. 5242, 1957 DOI: 10.1021/ja01576a047Organic Syntheses, Coll. Vol. 3, p. 475, 1955 | | Purification Methods | Crystallise indazole from water, sublime it in vacuo, then recrystallise it from pet ether (b 60-80o). The picrate crystallises from Et2O with m 136o. [Ainsworth Org Synth Coll Vol IV 536 1963, Beilstein 23 III/IV 1055, 23/6 V 156.] |
| Indazole Preparation Products And Raw materials |
| Raw materials | Acetic acid-->Nitric acid-->Sodium nitrite-->Acetic anhydride-->Benzene-->Sodium acetate-->Anthranilic acid-->o-Toluidine-->Phosphorus-->Hydriodic acid-->1H-Indazole, 1-[(4-methylphenyl)sulfonyl]--->2,2-dimethyl-5-(phenylhydrazinylidene)-1,3-dioxane-4,6-dione-->1H-Indazole, 3-(trimethylsilyl)--->1H-Indazole, 3-fluoro--->4-BROMO (1H)INDAZOLE-->4-FLUORO (1H)INDAZOLE-->4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-1H-INDAZOLE-->phenylcyanamide | | Preparation Products | GRANISETRON-D3 |
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