Product

Bis(2-chloroethyl)amine hydrochloride

CAS No.：821-48-7

Other grades of this product :

Bis(2-chloroethyl)amine hydrochloride Basic information

Product Name:	Bis(2-chloroethyl)amine hydrochloride
Synonyms:	BIS (2-CHLOROETHYL) AMINE HCL;BIS(2-CHLOROETHYL)AMINE HYDROCHLORIDE;BIS(2-CHLOROETHYL)AMMONIUM CHLORIDE;DI-(2-CHLOROETHYL)AMINE HYDROCHLORIDE;2,2'-DICHLORODIETHYLAMINE HYDROCHLORIDE;2,2’-dichloro-diethylaminhydrochloride;2-chloro-n-(2-chloroethyl)ethanaminehydrochloride;2-chloro-n-(2-chloroethyl)-ethanaminhydrochloride
CAS:	821-48-7
MF:	C4H10Cl3N
MW:	178.49
EINECS:	212-479-5
Product Categories:	Amines, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;Pharmaceutical Intermediates;Amine Salts;Nitrogen Compounds;Organic Building Blocks
Mol File:	821-48-7.mol

Bis(2-chloroethyl)amine hydrochloride Chemical Properties

Melting point	212-214 °C(lit.)
storage temp.	Store below +30°C.
solubility	>100g/l
form	Crystalline Powder
color	White to beige
Water Solubility	SOLUBLE
Sensitive	Hygroscopic
BRN	3550356
CAS DataBase Reference	821-48-7(CAS DataBase Reference)
NIST Chemistry Reference	2,2'-Dichlorodiethylamine hydrochloride(821-48-7)
EPA Substance Registry System	Ethanamine, 2-chloro-N-(2-chloroethyl)-, hydrochloride (821-48-7)

Safety Information

Hazard Codes	Xi,T,C
Risk Statements	36/37/38-36-34
Safety Statements	26-45-36/37/39-27
RIDADR	2811
WGK Germany	3
RTECS	IA1225000
Hazard Note	Irritant/Toxic
TSCA	Yes
HazardClass	8
PackingGroup	III
HS Code	29211980
Toxicity	LD50 orally in Rabbit: 1150 mg/kg

MSDS Information

Provider	Language
Bis(2-chloroethyl)amine hydrochloride	English
SigmaAldrich	English
ACROS	English
ALFA	English

Bis(2-chloroethyl)amine hydrochloride Usage And Synthesis

Chemical Properties	white to beige crystalline powder
Uses	A cytotoxic metabolite of Cyclophosphamide; a deuterated analog of Nor-nitrogen mustard.
Uses	Bis(2-chloroethyl)amine hydrochloride is used as an intermediate in chemicals synthesis and building block for piperazine derivatives.
Safety Profile	A poison by inhalation,intraperitoneal, intramuscular, and subcutaneous routes.An experimental teratogen. Human mutation datareported. When heated to decomposition it emits toxicfumes of NH3, NOx, and Cl-.
Purification Methods	Crystallise the salt from Me2CO or MeOH/Et2O. The picrate has m 112-113o (from EtOH or Me2CO). [Mann J Chem Soc 464 1934, Ward J Am Chem Soc 57 915 1935,

Bis(2-chloroethyl)amine hydrochloride Preparation Products And Raw materials

Raw materials

Diethanolamine

Preparation Products

1-CYCLOPROPYLPIPERAZINE-->(4-PHENYL-PIPERAZIN-1-YL)-ACETIC ACID-->1-AMINO-4-(2-HYDROXYETHYL)PIPERAZINE-->N-(3-Trifluoromethylphenyl)piperazine-->4-CYANO-4-PHENYLPIPERIDINE HYDROCHLORIDE-->3-(4-PHENYL-PIPERAZIN-1-YL)-PROPIONIC ACID-->1-(3-NITROPHENYL)-PIPERAZINE-->Thiomorpholine-->1-(3,5-DICHLOROPHENYL)PIPERAZINE-->1-(3-FLUOROPHENYL)PIPERAZINE-->1-(1-PHENYLETHYL)PIPERAZINE-->1-(4-Methoxyphenyl)piperazine-->1-(3-Chlorophenyl)piperazine dihydrochloride-->3-(4-methylpiperazin-1-yl)phenylboronic acid-->1-(3,4-Dichlorophenyl)piperazine-->1-(4-Methoxyphenyl)piperazine dihydrochloride-->4-(4-Methylpiperazin-1-yl)phenylboronic Acid-->1-[2-(MORPHOLIN-4-YL)-ETHYL]-PIPERAZINE-->1-(2-Methoxyphenyl)piperazine hydrobromide-->1-(3-METHYLPHENYL)PIPERAZINE-->1-(3-Methoxyphenyl)piperazine-->1-(2-FLUOROPHENYL)PIPERAZINE HYDROCHLORIDE-->1-(2-ETHOXYPHENYL)PIPERAZINE HYDROCHLORIDE-->N-Boc-N,N-bis(2-chloroethyl)amine-->1-(4-Chlorophenyl)piperazine-->1-(2-Methylphenyl)piperazine-->1-(4-METHYLPHENYL)PIPERAZINE-->1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE-->N-(2-Methylphenyl)piperazine hydrochloride

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