(±)-Cloprostenol sodium salt

CAS No.：55028-72-3

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
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(±)-Cloprostenol sodium salt Basic information

Product Name:	(±)-Cloprostenol sodium salt
Synonyms:	15-EPI CLOPROSTENOL;15(S)-CLOPROSTENOL;16-(3-CHLOROPHENOXY)-9,11,15R-TRIHYDROXY-17,18,19,20-TETRANORPROSTA-5Z,13E-DIEN-1-OIC ACID SODIUM SALT;(+)-16-M-CHLOROPHENOXY TETRANOR PROSTAGLANDIN F2ALPHA SODIUM SALT;7-(2-[4-(3-Chlorophenoxy)-3-hydroxy-1-butenyl]-3,5-dihydroxycyclopentyl)-5-heptenoic acid;(5Z)-rel-Cloprostenol SodiuM;DL-Cloprostenol sodiuM;(+/-)-16-(3-Chlorophenoxy)-9,11,15R-trihydroxy-17,18,19,20-tetranorprosta-5Z,13E-dien-1-oic acid hydrate sodium salt
CAS:	55028-72-3
MF:	C22H30ClNaO6
MW:	448.92
EINECS:	259-439-3
Product Categories:	Other APIs;Pharmaceuticals;Pharmaceutical Raw Materials;Prostaglandins;Chiral Reagents;Intermediates & Fine Chemicals
Mol File:	55028-72-3.mol

(±)-Cloprostenol sodium salt Chemical Properties

Melting point	68-70 °C
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	H₂O: >10 mg/mL
form	solid
color	light brown
InChIKey	IFEJLMHZNQJGQU-KXXGZHCCSA-M
CAS DataBase Reference	55028-72-3(CAS DataBase Reference)

Safety Information

Hazard Codes	T
Risk Statements	60-22-36/37/38
Safety Statements	53-26-36/37/39-45
WGK Germany	3
HS Code	2937500000

MSDS Information

(±)-Cloprostenol sodium salt Usage And Synthesis

Description	±)-Cloprostenol sodium salt is the d-enantiomer of Cloprostenol (C587300), an aryl-oxymethyl analog of prostaglandin F2α.
Uses	(±)-Cloprostenol sodium salt is a prostaglandin that dissolves the corpus luteum of cattle and is used as a veterinary drug.
Brand name	Estrumate(Bayer Animal Health).
General Description	Cloprostenol sodium (Estrumate)is available as the sodium salt from Bayer AgriculturalDivision or Bayvet Division of Miles Laboratory as an aqueoussolution containing 250 mg/mL.
Biological Activity	Water-soluble prostaglandin F 2 α (PGF 2 α ) analog; acts as a potent FP receptor agonist (EC 50 = 0.84 nM). Potently inhibits differentiation of adipocyte precursor cells. Luteolytic agent in vivo .
Veterinary Drugs and Treatments	Cloprostenol is approved for use in beef or dairy cattle to induce luteolysis. It is recommended by the manufacturer for unobserved or undetected estrus in cows cycling normally, pyometra or chronic endometritis, expulsion of mummified fetus, luteal cysts, induced abortions after mismating, and to schedule estrus and ovulation for controlled breeding. Cloprostenol has been used in dogs for pregnancy termination and treatment of open pyometra. The use of cloprostenol for pyometra is controversial as some believe dinoprost (PGF2alpha) is more effective and has fewer adverse effects than cloprostenol.
Solubility in water	Soluble in H₂O.

(±)-Cloprostenol sodium salt Preparation Products And Raw materials

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