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| 5-FLUORO-1,3-DIMETHYLURACIL Basic information |
| Product Name: | 5-FLUORO-1,3-DIMETHYLURACIL | | Synonyms: | 1,3-Dimethyl-5-fluorouracil, 2,4-Dihydroxy-1,3-dimethyl-5-fluoropyrimidine;5-fluoro-1,3-diMethylpyriMidine-2,4(1H,3H)-dione;5-FLUORO-1,3-DIMETHYLURACIL;1,3-dimethyl-5-fluorouracil;2,4(1H,3H)-Pyrimidinedione,5-fluoro-1,3-dimethyl-;Fluorouracil-001;5-Fluoro-1,3-dimethyluracil 99%;5-fluoro-1,3-dimethylpyrimidine-2,4-dione | | CAS: | 3013-92-1 | | MF: | C6H7FN2O2 | | MW: | 158.13 | | EINECS: | | Product Categories: | | Mol File: | 3013-92-1.mol |
| 5-FLUORO-1,3-DIMETHYLURACIL Chemical Properties |
| Melting point | 132-134 °C(lit.) | | Boiling point | 182.5±50.0 °C(Predicted) | | density | 1.37±0.1 g/cm3(Predicted) | | pka | -4.07±0.40(Predicted) | | BRN | 880396 |
| 5-FLUORO-1,3-DIMETHYLURACIL Usage And Synthesis |
| Uses | 5-Fluoro-1,3-dimethyluracil may be used as starting material in the following processes:- Regioselective synthesis of tetrahydronaphthocyclobuta[1,2-d]pyrimidinediones.
- To synthesize 5-bis(ethoxycarbonyl)methyl-1,3-dimethyluracil.
- To synthesize new highly conjugated propenylidene derivatives via aromatic Paterno-Buchi type cycloaddition with 1-methoxynaphthalene.
| | Synthesis Reference(s) | Tetrahedron, 46, p. 3093, 1990 DOI: 10.1016/S0040-4020(01)88400-3 | | General Description | Oxidation of 5-fluoro-1,3-dimethyluracil (5-FDMU) with m-chloroperbenzoic acid has been described. It is reported as antineoplastic drug. On photoirradiation, 5-fluoro-1,3-dimethyluracil yields the trans-anti cyclobutane dimer and the cis-syn cyclobutane dimer. UV irradiation of 5-FDMU and naphthalene in a protic medium affords 5-(1-naphthyl)uracil, while in aprotic media it undergoes stereoselective 1,4-cycloaddition reaction to give a barrelene derivative. The thermochemical parameters of 5-FDMU has been determined. It reacts with substituted benzenes in the presence of trifluoroacetic acid to generate 5-aryl-1,3-dimethyluracils via photosubstitution. |
| 5-FLUORO-1,3-DIMETHYLURACIL Preparation Products And Raw materials |
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