Product

5'-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-BETA-D-RIBOFURANOSYL 5'-MONOPHOSPHATE

CAS No.：3031-94-5

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5'-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-BETA-D-RIBOFURANOSYL 5'-MONOPHOSPHATE Basic information

Product Name:	5'-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-BETA-D-RIBOFURANOSYL 5'-MONOPHOSPHATE
Synonyms:	AICAR monophosphate, ZMP, N1-(β-D-5μ-Phosphoribofuranosyl)-5-aminoimidazole-4-carboxamide;1-(5-O-Phosphono-β-D-ribofuranosyl)-5-amino-1H-imidazole-4-carboxamide;5-Amino-1-(5-O-phosphono-β-D-ribofuranosyl)-1H-imidazole-4-carboxamide;5-Amino-4-imidazolecarboxamide ribonucleotide;5'-Phosphoribosyl-4-carboxamide-5-aminoimidazole;ZMP;5-Aino-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazole-4-carboxamide;5-Aminomidazole-4-carboxamide-1-β-D-ribofuranosyl 5-Monophosphate
CAS:	3031-94-5
MF:	C9H15N4O8P
MW:	338.21
EINECS:	221-212-1
Product Categories:	Bases & Related Reagents;Carbohydrates & Derivatives;Nucleotides
Mol File:	3031-94-5.mol

5'-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-BETA-D-RIBOFURANOSYL 5'-MONOPHOSPHATE Chemical Properties

Melting point	198-202°C dec.
Boiling point	845.3±75.0 °C(Predicted)
density	2.30±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO (Slightly, Heated, Sonicated), Methanol (Slightly), Water (Slightly)
pka	1.86±0.10(Predicted)
form	White to light pink solid
color	White to Pink
optical activity	[α]/D -69.0±3.0°, c = 0.1 in sodium bicarbonate
Stability:	Hygroscopic
InChIKey	UDYDDOATBNVEES-UUOKFMHZSA-N

Safety Information

Safety Statements	24/25
WGK Germany	3
HS Code	29349990

MSDS Information

Provider	Language
SigmaAldrich	English

5'-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-BETA-D-RIBOFURANOSYL 5'-MONOPHOSPHATE Usage And Synthesis

Chemical Properties	White Powder With Pink Tinge.
Uses	AICAR monophosphate is a 5′′-phosphorylated analog of cell permeable AICAR that mimics AMP. AICAR is an adenosine monophophate (AMP)-activated protein kinase (AMPK) activator/agonist.
General Description	5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranosyl 5′-monophosphate (AICAR monophosphate) is an intermediate metabolite in the purine de novo synthesis pathway and a potent activator of the human AMP-activated protein kinase (AMPK) activity in vitro. It can play an important regulatory role.
Biochem/physiol Actions	A 5′-phosphorylated analog of cell permeable AICAR that mimics adenosine monophosphate (AMP). It is an AMP-activated protein kinase (AMPK) activator.In humans, 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranosyl 5′-monophosphate (AICAR) is found to be accumulated in numerous metabolic diseases. It can increase the endurance of sedentary mice. AICAR exhibits antiproliferative effects. It can induce apoptosis of aneuploid cells.

5'-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-BETA-D-RIBOFURANOSYL 5'-MONOPHOSPHATE Preparation Products And Raw materials

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