Other grades of this product :
| Product Name: | E 7010 | | Synonyms: | E 7010;N-[2-(4-HYDROXYANILINO)PYRIDIN-3-YL]-4-METHOXYBENZENE-1-SULFONAMIDE;N-[2-[(4-Hydroxyphenyl)amino]-3-pyridyl]-4-methoxybenzenesulfonamide;BenzenesulfonaMide, N-[2-[(4-hydroxyphenyl)aMino]-3-pyridinyl]-4-Methoxy-;ABT-751 (E7010);N-(2-(4-hydroxyphenylamino)pyridin-3-yl)-4-methoxybenzenesulfonamide;ABT-751 (E;E7010(ABT-751) | | CAS: | 141430-65-1 | | MF: | C18H17N3O4S | | MW: | 371.41 | | EINECS: | 256-495-9 | | Product Categories: | Inhibitors | | Mol File: | 141430-65-1.mol |
| E 7010 Chemical Properties |
| Melting point | 162 °C(dec.) | | Boiling point | 551.0±60.0 °C(Predicted) | | density | 1.427 | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | insoluble in H2O; ≥18.55 mg/mL in DMSO; ≥25.53 mg/mL in EtOH with ultrasonic | | form | powder to crystal | | pka | 7.86±0.40(Predicted) | | color | White to Yellow to Orange |
| E 7010 Usage And Synthesis |
| Description | ABT-751 is a tubulin polymerization inhibitor that binds to the colchicine binding site on β-tubulin (Ki = 3.3 μM). It inhibits tubulin polymerization in a concentration-dependent manner and inhibits growth of 26 human tumor cell lines (IC50s = 0.06-0.08 μg/ml). ABT-751 (100 mg/kg, p.o.) induces tumor regression in NB-1382 neuroblastoma, IRS56 rhabdomyosarcoma, and KT-6 Wilms mouse xenograft models. It also induces tumor endothelial cell retraction and reduces tumor perfusion, but not muscle perfusion, in a 9L rat glioma subcutaneous tumor model. |
| E 7010 Preparation Products And Raw materials |
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