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| 2-Hydroxypyridine Basic information |
| 2-Hydroxypyridine Chemical Properties |
| Melting point | 105-107 °C (lit.) | | Boiling point | 280-281 °C (lit.) | | density | 1.39 | | refractive index | 1.5939 (estimate) | | Fp | 210 °C | | storage temp. | Sealed in dry,Room Temperature | | solubility | 450g/l | | pka | 0.75(at 20℃) | | form | Liquid | | color | Colorless to yellow to brown, darken on storage with no loss of purity | | Water Solubility | Soluble in water 450 g/L @ 20°C and ethanol, slightly soluble in benzene and ether. | | BRN | 105786 | | CAS DataBase Reference | 142-08-5(CAS DataBase Reference) | | NIST Chemistry Reference | 2(1H)-Pyridinone(142-08-5) | | EPA Substance Registry System | 2(1H)-Pyridinone (142-08-5) |
| Hazard Codes | Xi,Xn,T | | Risk Statements | 36/37/38-40-25 | | Safety Statements | 26-36-37/39-22-45-36/37/39 | | RIDADR | UN2811 | | WGK Germany | 3 | | RTECS | UV1144050 | | F | 8 | | TSCA | Yes | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29333990 | | Toxicity | LD50 ipr-mus: 410 mg/kg TOXIA6 23,815,85 |
| 2-Hydroxypyridine Usage And Synthesis |
| Chemical Properties | white to light yellow crystal | | Uses | Catalyst for generating β-oxopropyl carbonates from cyclic carbonates and alcohols and in the aminolysis of a polyglutamate.
| | Uses | 2-Hydroxypyridine is a bifunctional catalyst for a wide variety of acylation reactions, catalyst for generating β-oxopropyl carbonates from cyclic carbonates and alcohols and in the aminolysis of a polyglutamate. It is used in peptide synthesis. | | Definition | ChEBI: 2-Hydroxypyridine is a monohydroxypyridine that is pyridine substituted by a hydroxy group at position 2. It has a role as a plant metabolite. | | General Description | 2-Hydroxypyridine, an enolic tautomer of 2-pyridone, belongs to the class of volatile organic compounds (VOCs). | | Safety Profile | Moderately toxic by intraperitoneal and intravenous routes. A combustible liquid. When heated to decomposition it emits toxic vapors of NOx. | | Purification Methods | Distil the pyridone under vacuum to remove coloured impurity, then recrystallise from *benzene, CCl4, EtOH or CHCl3/diethyl ether. It can be sublimed under high vacuum. [DePue et al. J Am Chem Soc 107 2131 1985, Beilstein 21/7 V 106.] |
| 2-Hydroxypyridine Preparation Products And Raw materials |
| Raw materials | 1,3-Dicyclohexylthiourea-->Allyl isothiocyanate-->Dicyclohexylcarbodiimide-->Carbonic acid, 1,1-dimethylethyl 2-pyridinyl ester (9CI)-->2(1H)-Pyridinone, 1-[[(4-methoxy-1-naphthalenyl)carbonyl]oxy]- (9CI)-->BOC-L-Tyrosine | | Preparation Products | 2-Hydroxy-5-bromopyridine-->DI-2-PYRIDYL THIONOCARBONATE-->Reactive Brilliant Yellow M-7G-->5-CHLOROPYRIDIN-2(1H)-ONE-->3,5-DICHLORO-2-PYRIDONE-->disodium 4-[[5-(aminocarbonyl)-1-ethyl-1,6-dihydro-2-hydroxy-4-methyl-6-oxo-3-pyridyl]azo]-6-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]benzene-1,3-disulphonate-->2,3-Dihydroxypyridine-->(2-OXOPYRIDIN-1(2H)-YL)ACETIC ACID-->2-HYDRAZINO-3-NITROPYRIDINE |
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