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| 2α,5α-Epoxy-1,2-dihydroakuammilan-17-oic acid methyl ester Basic information |
| Product Name: | 2α,5α-Epoxy-1,2-dihydroakuammilan-17-oic acid methyl ester | | Synonyms: | 2α,5α-Epoxy-1,2-dihydroakuammilan-17-oic acid methyl ester;Picrinine;2H,12H-6,12A-Epoxy-2,7A-methanoindolo[2,3-A]quinolizine-14-carboxylic acid, 3-ethylidene-1,3,4,6,7,12B-hexahydro-, methyl ester, (2S,3E,6S,12ar,12bs)-;Inchi=1/C20H22N2o3/C1-3-11-10-22-15-8-12(11)17(18(23)24-2)19-9-16(22)25-20(15,19)21-14-7-5-4-6-13(14)19/H3-7,12,15-17,21H,8-10H2,1-2H3/B11-3-/T12-,15+,16+,17,19,20+/m1/s;Methyl (2alpha,5alpha,15alpha,16xi,19E)-1,2-dihydro-2,5-epoxyakuammilan-17-oate;Picrinin;Picrinine ,98%;GenericnaMe | | CAS: | 4684-32-6 | | MF: | C20H22N2O3 | | MW: | 338.41 | | EINECS: | | Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract | | Mol File: | 4684-32-6.mol |
| 2α,5α-Epoxy-1,2-dihydroakuammilan-17-oic acid methyl ester Chemical Properties |
| Melting point | 222-224 °C | | Boiling point | 501.1±50.0 °C(Predicted) | | density | 1.38±0.1 g/cm3(Predicted) | | pka | 4.47±0.40(Predicted) |
| 2α,5α-Epoxy-1,2-dihydroakuammilan-17-oic acid methyl ester Usage And Synthesis |
| Description | An Alstonia alkaloid obtained from A. scholaris R. Br., this base also occurs in
Rauwolfia vornitora. It has [α]D - 47° (CHCI3). The ultraviolet spectrum in
neutral solution (EtOH) has absorption maxima at 237 and 287 mil, while in
acidic solution (perchloric acid), there are absorption maxima at 239, 244 and
305 mil. A methoxycarbonyl group, an alkyl group and an ether bridge are present
in the molecule. The picrate is obtained as light yellow crystals with m.p. 172-
4°C (dec.) and the methiodide has m.p. 235-7°C. | | Uses | Picrinine is a monoterpenoid indole alkaloid extracted from Ochrosia elliptica, displaing the enhancement of immunomodulatory activity and apaptosis inducing in the A549 cell lines. | | References | Preparation:
Britten, Smith.,J. Chern. Soc., 3850 (1963)
Isolation:
Chatterjee et al., Tetrahedron Lett., 3633 (1965) |
| 2α,5α-Epoxy-1,2-dihydroakuammilan-17-oic acid methyl ester Preparation Products And Raw materials |
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