| 4-(Trifluoromethyl)phenylacetic acid Basic information |
| Product Name: | 4-(Trifluoromethyl)phenylacetic acid |
| Synonyms: | (alpha,alpha,alpha-trifluoro-4-tolyl)acetic acid;2-(4-(TRIFLUOROMETHYL)PHENYL)ACETIC ACID;(α,α,α-Trifluoro-p-tolyl)acetic acid;4-(Trifluoromethyl)Phenylaceti;(à,à,à-trifluoro-p-tolyl)acetic acid;4-(Trifluoromethyl)phenylacetic acid 98%;4-(Trifluoromethyl)phenylaceticacid98%;(A,A,A-TRIFLUORO-P-TOLY)ACETIC ACID |
| CAS: | 32857-62-8 |
| MF: | C9H7F3O2 |
| MW: | 204.15 |
| EINECS: | 251-263-5 |
| Product Categories: | Aromatic Phenylacetic Acids and Derivatives;Phenylacetic acid;Acids and Derivatives;Pyridines ,Heterocyclic Acids |
| Mol File: | 32857-62-8.mol |
| 4-(Trifluoromethyl)phenylacetic acid Chemical Properties |
| Melting point | 82-85 °C(lit.) |
| Boiling point | 203°C (rough estimate) |
| density | 1.2815 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 4.01±0.10(Predicted) |
| form | Crystals or Crystalline Powder |
| color | White to very pale yellow |
| BRN | 2267687 |
| CAS DataBase Reference | 32857-62-8(CAS DataBase Reference) |
| NIST Chemistry Reference | («ALPHA»,«alpha»,«alpha»-trifluoro-p-tolyl)-acetic acid(32857-62-8) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-37/39-36 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 29163990 |
| MSDS Information |
| Provider | Language |
|---|---|
| ACROS | English |
| SigmaAldrich | English |
| ALFA | English |
| 4-(Trifluoromethyl)phenylacetic acid Usage And Synthesis |
| Chemical Properties | white to very pale yellow crystals or |
| Uses | 4-(Trifluoromethyl)benzeneacetic Acid is an intermediate used to synthesize PPARγ/δ dual agonists via solid-Phase parallel synthesis. It was also used to prepare heterocyclic xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists. |
| General Description | 4-(Trifluoromethyl)phenylacetic acid undergoes diolefination mediated by mono-N-protected amino acid ligands in the presence of ethyl acrylate, Pd(OAc)2, KHCO3 and t-amyl alcohol. |
| 4-(Trifluoromethyl)phenylacetic acid Preparation Products And Raw materials |
| Raw materials | Ethanol-->Sodium hydroxide-->Ethyl acetate-->Tetrahydrofuran-->Dichloromethane-->PETROLEUM ETHER-->Magnesium-->4-(Trifluoromethoxy)benzyl bromide |
| Preparation Products | 2-NITRO-4-(TRIFLUOROMETHYL)PHENYLACETIC ACID |
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