Other grades of this product :
| Chorionic Gonadotropin Basic information |
| Chorionic Gonadotropin Chemical Properties |
| storage temp. | 2-8°C | | solubility | H2O: soluble1ML/vial | | form | lyophilized powder |
| Chorionic Gonadotropin Usage And Synthesis |
| Chemical Properties | White or yellowish-white, amorphous powder. | | Uses | Gonad-stimulating principle. | | Uses | Chorionic gonadotropin human has been used: - to induce oocyte maturation in cultured follicles
- along with pregnant mare serum gonadotropin (PMSG) to induce superovulation in mice
- as medium component for fetal testes culture to aid steroidogenic responsiveness
| | Production Methods | CG is produced in the chorion.
| | Brand name | A.P.L. (Ferring Pharmaceuticals); Follutein (Bristol-Myers
Squibb); Pregnyl (Organon). | | General Description | Glycoprotein hormone consisting of a 92-amino acid α-chain which is identical to that of LH, FSH, and TSH; and a distinct 149-amino acid β-chain. Produced by chorionic tissue and responsible for maintaining the corpus luteum during early pregnancy. Also produced by trophoblast cell neoplasms, which are marked by elevated free hCG β-chains and hyperglycosylated hCG. | | Biochem/physiol Actions | Elevated levels of hCG is observed in trophoblastic cancer. hCG levels are indicators of pregnancy and β subunit is majorly present in urine samples. hCG isoform detection is useful in the diagnosis and management of trophoblastic related diseases including carcinomas. | | Clinical Use | Choriogonadotropin alfa is obtained by rDNA technology and is biologically and chemically
identical to hCG of natural origin. It is used, like hCG of natural origin, for inducing ovulation in
women with anovulatory infertility. Following proper pretreatment with a GnRH antagonist or
superagonist to desensitize the pituitary, women participating in ART are treated with a folliclestimulating agent (e.g., menotropins) to effect the final maturation of the follicles within the
ovaries. Ultrasonograms are used to determine proper follicle maturation before the
administration of choriogonadotropin alfa to induce ovulation. A distinct advantage of this
product is that it can be self-administered by the patient via SC injection. | | Veterinary Drugs and Treatments | The veterinary product’s labeled indication is for “parenteral use
in cows for the treatment of nymphomania (frequent or constant
heat) due to cystic ovaries.” It has been used for other purposes in
several species; refer to the Dosage section for more information. |
| Chorionic Gonadotropin Preparation Products And Raw materials |
| Raw materials | Ethanol-->Sodium chloride-->Sodium acetate trihydrate-->Ammonium sulfate-->Acetamide-->Benzoic acid-->Aluminium potassium sulfate dodecahydrate-->Calcium acetate-->Trisodium phosphate-->TRIS BORATE EDTA BUFFER, 10X, DNASE, RNASE AND PROTEASE FREE, PH 8.3, FOR MOLECULAR BIOLOGY-->ACETALDEHYDE AMMONIA-->HEMOGLOBIN-->IGE, ANTI-HUMAN, GOAT, IGG FRAC, FITC, LQ-->Ethacridine lactate monohydrate |
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