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| N-acetyl aspartyl-glutaMic acid Basic information |
| Product Name: | N-acetyl aspartyl-glutaMic acid | | Synonyms: | SPAGLUMIC ACID;NAAG;N-ACETYL-L-ASPARTYL-L-GLUTAMIC ACID;N-ACETYLASPARTYLGLUTAMIC ACID;N-ACETYL-ASP-GLU;N-ACETYL-ASP-GLU-OH;ALPHA-NAAG;AC-ASP-GLU | | CAS: | 3106-85-2 | | MF: | C11H16N2O8 | | MW: | 304.25 | | EINECS: | | Product Categories: | | Mol File: | 3106-85-2.mol |
| N-acetyl aspartyl-glutaMic acid Chemical Properties |
| Melting point | 171-173 °C | | Boiling point | 769.5±60.0 °C(Predicted) | | density | 1.472±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | H2O: 50 mg/mL | | form | powder | | pka | 3.04±0.10(Predicted) | | color | white | | optical activity | [α]22/D 34.5°, c = 1.1 in H2O(lit.) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | HS Code | 29241990 |
| N-acetyl aspartyl-glutaMic acid Usage And Synthesis |
| Chemical Properties | White powder | | Uses | N-acetyl aspartyl-glutamic acid is a spaglumic acid is a marker of neuronal integrity and was used in the detection of therapeutic values of antidrepressant treatments.
| | Uses | N-Acetyl-Asp-Glu has been used in N-acetylated α-linked acidic dipeptidase (NAALADase) assay and affinity experiments. | | Definition | ChEBI: A dipeptide composed of N-acetyl-L-aspartic acid and L-glutamic acid joined by a peptide linkage. | | General Description | NAAG is a neuropeptide and a neurotransmitter that is abundant in the mammalian nervous system. It remains uncertain whether this compound activates NMDA receptors; however, it is clearly demonstrated to act as a selective agonist of mGluR3, both in vitro and in vivo. | | Biochem/physiol Actions | Endogenous neurotransmitter localized to neurons with high affinity for metabotropic glutamate receptors, mGluR3. It is an antagonist at NMDA receptors. Catabolized by carboxypeptidase II, which is expressed on astrocyte membranes, to N-acetylaspartate and glutamate. |
| N-acetyl aspartyl-glutaMic acid Preparation Products And Raw materials |
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