N-acetyl aspartyl-glutaMic acid

CAS No.：3106-85-2

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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N-acetyl aspartyl-glutaMic acid Basic information

Product Name:	N-acetyl aspartyl-glutaMic acid
Synonyms:	SPAGLUMIC ACID;NAAG;N-ACETYL-L-ASPARTYL-L-GLUTAMIC ACID;N-ACETYLASPARTYLGLUTAMIC ACID;N-ACETYL-ASP-GLU;N-ACETYL-ASP-GLU-OH;ALPHA-NAAG;AC-ASP-GLU
CAS:	3106-85-2
MF:	C11H16N2O8
MW:	304.25
EINECS:
Product Categories:
Mol File:	3106-85-2.mol

N-acetyl aspartyl-glutaMic acid Chemical Properties

Melting point	171-173 °C
Boiling point	769.5±60.0 °C(Predicted)
density	1.472±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	H₂O: 50 mg/mL
form	powder
pka	3.04±0.10(Predicted)
color	white
optical activity	[α]22/D 34.5°, c = 1.1 in H2O(lit.)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
HS Code	29241990

MSDS Information

Provider	Language
SigmaAldrich	English

N-acetyl aspartyl-glutaMic acid Usage And Synthesis

Chemical Properties	White powder
Uses	N-acetyl aspartyl-glutamic acid is a spaglumic acid is a marker of neuronal integrity and was used in the detection of therapeutic values of antidrepressant treatments.
Uses	N-Acetyl-Asp-Glu has been used in N-acetylated α-linked acidic dipeptidase (NAALADase) assay and affinity experiments.
Definition	ChEBI: A dipeptide composed of N-acetyl-L-aspartic acid and L-glutamic acid joined by a peptide linkage.
General Description	NAAG is a neuropeptide and a neurotransmitter that is abundant in the mammalian nervous system. It remains uncertain whether this compound activates NMDA receptors; however, it is clearly demonstrated to act as a selective agonist of mGluR3, both in vitro and in vivo.
Biochem/physiol Actions	Endogenous neurotransmitter localized to neurons with high affinity for metabotropic glutamate receptors, mGluR3. It is an antagonist at NMDA receptors. Catabolized by carboxypeptidase II, which is expressed on astrocyte membranes, to N-acetylaspartate and glutamate.

N-acetyl aspartyl-glutaMic acid Preparation Products And Raw materials

Preparation Products

L-Glutamic acid

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