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| 1-Bromo-3-chloropropane Basic information |
| 1-Bromo-3-chloropropane Chemical Properties |
| 1-Bromo-3-chloropropane Usage And Synthesis |
| Chemical Properties | clear colorless liquid. Soluble in ethanol, ether and chloroform, insoluble in water. | | Uses | 1-Bromo-3-chloropropane can be used safer and equally efficient alternative to chloroform as a phase-separation agent in the 1-step method of RNA isolation from biological samples such as animal and plant tissue. It is a replacement for CHCl3 in RNA phase separations. | | Application | 1-Bromo-3-chloropropane is used in the preparation active pharmaceutical ingredient intermediate such as gemfibrozil and reproterol. It is also involved in the preparation of cardiovascular diseases and analgesic drugs materials. It is utilized as a phase separation reagent for the isolation of ribonucleic acid (RNA) in high quality. It is considered as a replacement of chloroform in nucleic acid separations. | | Preparation | 1-Bromo-3-chloropropane is virtually always produced by the free-radical addition of anhydrous hydrogen bromide to allyl chloride. It can also be made from ethylene and methylene chlorobromide. | | General Description | 1-bromo-3-chloropropane appears as a colorless liquid. Insoluble in water and denser than water. May be toxic by inhalation, ingestion or skin absorption. Used to make pharmaceuticals and other chemicals. | | Air & Water Reactions | Insoluble in water. | | Reactivity Profile | Halogenated aliphatic compounds, such as 1-Bromo-3-chloropropane, are moderately or very reactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group are incompatible with strong oxidizing and reducing agents. Also, they are incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides. | | Health Hazard | Inhalation of vapors or dust is extremely irritating. May cause burning of eyes and flow of tears. May cause coughing, difficult breathing and nausea. Brief exposure effects last only a few minutes. Exposure in an enclosed area may be very harmful. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may cause pollution. | | Fire Hazard | Some of these materials may burn, but none ignite readily. Containers may explode when heated. | | Safety Profile | Moderately toxic by
ingestion. When heated to decomposition it
emits toxic fumes of Cland Br-. See also
CHLORINATED HYDROCARBONS,
ALIPHATIC; and BROMIDES. | | Purification Methods | Wash it with conc H2SO4, water, 10% Na2CO3 solution, water again and then dry with CaCl2 and fractionally distil it just before use [Akagi et al. J Am Chem Soc 78 4034 1956]. [Beilstein 1 H 109, 1 IV 212.] |
| 1-Bromo-3-chloropropane Preparation Products And Raw materials |
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