Other grades of this product :
| 1-Hydroxybenzotriazole hydrate Basic information |
| 1-Hydroxybenzotriazole hydrate Chemical Properties |
| Melting point | 155-158 °C(lit.) | | Boiling point | 248.8°C (rough estimate) | | density | 1.065 g/cm | | refractive index | 1.6910 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | DMF: 100 mg/mL, clear | | Water Solubility | slightly soluble | | BRN | 4515 | | CAS DataBase Reference | 123333-53-9(CAS DataBase Reference) |
| 1-Hydroxybenzotriazole hydrate Usage And Synthesis |
| Chemical Properties | White to off-white powder | | Uses | additive for oligonucleotide couplings and in racemization-free peptide couplings | | Uses | 1-Hydroxybenzotriazole hydrate can be used as a condensation reagent to prepare: - Poly-γ-glutamic acid methyl ester from a dimer of γ-glutamic acid.
- Oxadiazoles via cyclo condensation of amidoximes with trifluoroacetic anhydride or benzoic acid derivatives.
| | Uses | A common additive for peptide coupling.
| | General Description | 1-Hydroxybenzotriazole is a coupling reagent used to synthesize amides by the condensation reaction between the activated ester/acid and the amino group of protected amino acids. It is also used as a racemization suppressor during peptide synthesis. |
| 1-Hydroxybenzotriazole hydrate Preparation Products And Raw materials |
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