Other grades of this product :
| 4,5,6,7-TETRABROMOBENZOTRIAZOLE Basic information |
| Product Name: | 4,5,6,7-TETRABROMOBENZOTRIAZOLE | | Synonyms: | NSC 231634;TBB;TBBT;7-tetrabromo-;NSC 231634; TBB (ENZYME INHIBITOR);1H-BENZOTRIAZOLE; 4;5;6;7-TETRABROMO-;4,5,6,7-Tetrabromo-1H-benzotriazole;CASEIN KINASE II INHIBITOR *TBB**;4,5,6,7-Tetrabromo-2-azabenzimidazole, 4,5,6,7-Tetrabromobenzotriazole, NSC 231634, TBBt | | CAS: | 17374-26-4 | | MF: | C6HBr4N3 | | MW: | 434.71 | | EINECS: | | Product Categories: | Akt;mTOR;Protein Kinase;PI3K/Akt/mTOR;Inhibitors;PI3K;Protein Kinase Inhibitors and Activators | | Mol File: | 17374-26-4.mol |
| 4,5,6,7-TETRABROMOBENZOTRIAZOLE Chemical Properties |
| Melting point | 262-266°C | | Boiling point | 552.5±45.0 °C(Predicted) | | density | 2.840±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 28 mg/mL | | pka | 3.87±0.40(Predicted) | | form | solid | | color | white | | λmax | 300nm(MeOH)(lit.) |
| WGK Germany | 3 | | HS Code | 29349990 |
| 4,5,6,7-TETRABROMOBENZOTRIAZOLE Usage And Synthesis |
| Chemical Properties | Crystalline Solid | | Uses | TBB is one of the most selective protein kinase inhibitors known, and when tested against a panel of 33 serine/threonine and tyrosine protein kinases, only three exhibited moderate inhibition by TBB,
with Ki values one to two orders of magnitude higher than that for CK2. | | Uses | TBB is one of the most selective protein kinase inhibitors known, and when tested against a panel of 33 serine/threonine and tyrosine protein kinases, only three exhibited moderate inhibition by TBB, with Ki values one to two orders of magnitude higher than that for CK2. | | Biological Activity | A cell-permeable, selective inhibitor of casein kinase-2 (CK2) (IC 50 = 0.9 and 1.6 μ M for rat liver and human recombinant CK2 respectively). Exhibits modest discrimination between CK2 subunits, with K i values ranging from 80 nM to 210 nM. Acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases. | | Biochem/physiol Actions | TBB binds to the Val66 residue of casein kinase-2 and inhibits the binding of ATP/GTP. TBB is cell permeable; it induces caspase-dependent apoptosis and degrades hematopoietic lineage cell-specific protein 1 in Jurkat cells. |
| 4,5,6,7-TETRABROMOBENZOTRIAZOLE Preparation Products And Raw materials |
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