2-HYDROXY-5-METHYLISOPHTHALALDEHYDE

2-HYDROXY-5-METHYLISOPHTHALALDEHYDE
  • CAS No.:7310-95-4

Important Notice

  1. This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
  2. This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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2-HYDROXY-5-METHYLISOPHTHALALDEHYDE Basic information
Product Name:2-HYDROXY-5-METHYLISOPHTHALALDEHYDE
Synonyms:1,3-Benzenedicarboxaldehyde, 2-hydroxy-5-methyl-;AKOS BC-1725;2,6-DIFORMYL-4-METHYLPHENOL;2-HYDROXY-5-METHYLISOPHTHALALDEHYDE;2-HYDROXY-5-METHYLISOPHTHALDEHYDE;2-HYDROXY-5-METHYL-1,3-BENZENEDICARBOXALDEHYDE;2,6-Diformyl-4-methylphenol,99%;2-Hydroxy-5-methyl-1,3-benzenedicarbaldehyde
CAS:7310-95-4
MF:C9H8O3
MW:164.16
EINECS:230-768-4
Product Categories:Aldehydes;C9;Aromatic Aldehydes & Derivatives (substituted);Carbonyl Compounds
Mol File:7310-95-4.mol
2-HYDROXY-5-METHYLISOPHTHALALDEHYDE Chemical Properties
Melting point 128-130 °C (lit.)
Boiling point 251.61°C (rough estimate)
density 1.2132 (rough estimate)
refractive index 1.5380 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
pka6.69±0.23(Predicted)
form powder to crystal
color White to Yellow to Orange
CAS DataBase Reference7310-95-4(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
HazardClass IRRITANT
HS Code 29124990
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
2-HYDROXY-5-METHYLISOPHTHALALDEHYDE Usage And Synthesis
Chemical Propertieslight yellow to beige cryst. powder or needles
Uses2-Hydroxy-5-methyl-1,3-benzenedicarboxaldehyde (2-hydroxy-5-methylisophthalaldehyde) is suitable reagent used in the synthesis of 2-(2′-vinyloxyethoxy)-5-methylisophthaldehyde and chiral calixsalen macrocycles.2-Hydroxy-5-methyl-1,3-benzenedicarboxaldehyde may be used in the synthesis of the following:
  • 3-[(2,4-Dichlorophenyl)iminomethyl]-2-hydroxy-5-methylbenzaldehyde, a Schiff base.
  • 2-Hydroxy-3-methoxymethyl-5-methylbenzaldehyde.
  • Acyclic Schiff-base ligands.
  • Macrobicyclic ligands (MSB).
  • 4-Methyl-2,6-divinylphenol.
  • 2-Hydroxy-3-dimethoxymethyl-5-methylbenzaldehyde.
General Description2-Hydroxy-5-methyl-1,3-benzenedicarboxaldehyde (2-hydroxy-5-methylisophthalaldehyde) is a dialdehyde derivative. It has been synthesized by heating p-cresol with hexamethylenetetramine. The structure has been confirmed by 1H and 13C NMR. It is an important raw material for the synthesis of various binucleating schiff base ligand.
2-HYDROXY-5-METHYLISOPHTHALALDEHYDE Preparation Products And Raw materials
Raw materialsAcetic acid-->Paraformaldehyde-->Hexamethylenetetramine-->p-Cresol

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