Other grades of this product :
| 1-Aminobenzotriazole Basic information |
| 1-Aminobenzotriazole Chemical Properties |
| Melting point | 81-84 °C (lit.) | | Boiling point | 237.24°C (rough estimate) | | density | 1.2769 (rough estimate) | | refractive index | 1.7000 (estimate) | | RTECS | DM1235000 | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Soluble in DMSO (up to 30mg/ml) | | form | Crystalline Powder | | pka | 2.09±0.30(Predicted) | | color | Yellow to beige or light brown | | Water Solubility | slightly soluble | | BRN | 607843 | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. | | CAS DataBase Reference | 1614-12-6(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37/39 | | WGK Germany | 3 | | Hazard Note | Irritant | | HS Code | 29349990 |
| 1-Aminobenzotriazole Usage And Synthesis |
| Description | 1-Aminobenztriazole (1614-12-6) is a pan-specific cytochrome P450 inhibitor acting as a suicide substrate.1,2?Blocks omega-oxidation of arachidonic acid but not its epoxidation.3 | | Chemical Properties | yellow to beige or light brown crystalline powder | | Uses | 1-Aminobenzotriazole is used as a Suicide inhibitor of cytochrome P450 and chloroperoxidase, an inhibitor of oxidative drug metabolism in biochemical pharmacology and toxicology studies. | | Uses | 1-Aminobenzotriazole has been used as a cytochrome P450 inhibitor to study the effects of estrogen on H2O2-induced premature senescence of vascular smooth muscle cells from old rats It has also been used to study the estrogen receptor-mediated effects of 17β-estradiol. | | Biochem/physiol Actions | 1-Aminobenzotriazole (1-ABT) is used as an in vitro tool in drug discovery. It can differentiate the P450 from non-P450 enzyme systems. 1-ABT exhibits inhibitory action by covalent alteration of the heme prosthetic group in the P450 enzyme. | | References | 1) Mugford?et al.?(1995),?1-Aminobenzotriazole-Induced Destruction of Hepatic and Renal Cytochrome P450 in Male Sprague-Dawley Rats; Fundam. Appl. Tox.,?19?43
2) Emoto?et al.?(2005),?In Vitro Inhibitory Effect of 1-Aminobenzotriazole on Drug Oxidations in Human Liver Microsomes: A Comparison With SKF-525A; Drug Metab. Pharmacokinet.,?20?351
3) Su?et al.?(1998),?Inhibition of Renal Arachidonic Acid Omega-Hydroxylase Activity With ABT Reduces Blood Pressure in the SHR; Am. J. Physiol.,?275?R426 |
| 1-Aminobenzotriazole Preparation Products And Raw materials |
|
日本语
한국어
Français
Deutsch
España
Türkiye