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| WIN 55,212-2 MESYLATE Basic information |
| WIN 55,212-2 MESYLATE Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | ≥57.1 mg/mL in DMSO; insoluble in EtOH; ≥25.95 mg/mL in H2O | | form | solid |
| WIN 55,212-2 MESYLATE Usage And Synthesis |
| Biological Activity | sildenafil mesylate is an inhibitor of cyclic guanosine monophosphate (cgmp)-specific phosphodiesterase type 5 (pde5).pde5 is the predominant phosphodiesterase in the corpus cavernosum. the catalytic site of pde5 degrades cgmp, and pde5 inhibitors can potentiate endogenous increases in cgmp. | | in vitro | sildenafil mesylate had been identified as a potent pde5 reversible and selective inhibitor. sildenafil enhanced sodium nitroprusside- or transmural electrical stimulation-induced relaxation of precontracted corpus cavernosum muscle strips in organ baths. sildenafil also increased intracellular cgmp concentrations in cultured smooth muscle cells treated with sodium nitroprusside [1]. | | in vivo | in anesthetized dogs, sildenafil could enhance the erectile function following pelvic nerve stimulation as measured by increased intracavernosal pressure [1]. | | IC 50 | 3.5 nm | | references | [1] nehra a,colreavy f,khandheria bk,chandrasekaran k. sildenafil citrate, a selective phosphodiesterase type 5 inhibitor: urologic and cardiovascular implications. world j urol.2001 feb;19(1):40-5.[2] moore ra,edwards je,mcquay hj. sildenafil (viagra) for male erectile dysfunction: a meta-analysis of |
| WIN 55,212-2 MESYLATE Preparation Products And Raw materials |
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